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| Registros recuperados : 190 | |
| 61. |  | NESHICH, G.; JARDINE, J. G.; BERNARDES, R.; MAZONI, I.; MANCINI, A. L.; SILVEIRA, C. da. "Cloud computation" na forma de serviços WEB para um banco de dados federativo STING_RDB. In: SIMPÓSIO SOBRE INOVAÇÃO E CRIATIVIDADE CIENTÍFICA NA EMBRAPA, 1., 2008, Brasília, DF. Comunicações Selecionadas. Brasília, DF: Embrapa, 2008. Não paginado.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 63. | | MELO, R. C.; MAZONI, I.; NESHICH, G.; SANTORO, M. M.; MEIRA JÚNIOR, W. Contacts as the key elements for comparing two protein structures. In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006. Não paginado. ISMB, X-MEETING 2006. Poster I-6.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 65. | | SILVA, M. C. M. da; NESHICH, G.; CHRISPEELS, M.; HONIG, B.; SA, M. F. G. de. Molecular basis of the interactions between insect x-amylases and inhibitors. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE BIOQUIMICA E BIOLOGIA MOLECULAR, 28., 1999, Caxambu, MG. Programa e resumos. Caxambu: Sociedade Brasileira de Bioquimica e Biologia Molecular, 1999. p.35E-63.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 66. | | FERRAZ, L. F. C.; SOARDI, F.; FALCÃO, P.; NESHICH, G.; MELLO, M. P. de. Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia. In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006. Não paginado. ISMB, X-MEETING 2006. Poster D-12.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 67. | | MARCELLINO, L. H.; NESHICH, G.; GROSSI DE SA, M. F.; KREBBERS, E.; GANDER, E. S. Modified 2S albumins with improved tryptophan content are correctly expressed in transgenic tobacco plants. FEBS Letters, Amsterdam, v.385, n.3, p.154-158, 1996. p.154-158| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 69. | | SALIM, J. A.; BORRO, L.; MAZONI, I.; YANO, I. H.; JARDINE, J. G.; NESHICH, G. Multiple structure single parameter: analysis of a single protein nano environment descriptor characterizing a shared loci on structurally aligned proteins. Bioinformatics, v. 32, n. 12, p. 1885-1887, 2016.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 72. | | MAZONI, I.; BORRO, L. C.; ALVARENGA, D.; JARDINE, J. G.; NESHICH, G. Studying structure function relationship of proteins using "remediated" PDB files. In: ANNUAL MEETING OF SBBQ, 37.; CONGRESS OF THE PAN-AMERICAN ASSOCIATION FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 11, 2008, Águas de Lindóia. Program and index... Águas de Lindóia, Program and index... Águas de Lindóia: SBBq, 2008. Não paginado. PABMB.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 73. | | MAZONI, I.; BORRO, L. C.; JARDINE, J. G.; YANO, I. H.; SALIM, J. A.; NESHICH, G. Study of specific nanoenvironments containing [alfa]-helices in all-[alfa] and ([alfa]+[beta])+([alfa]/[beta]) proteins. Plos One, v. 13, n. 7, p. 1-25, 2018. Artigo e0200018.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Territorial. |
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| 79. | | FERNANDEZ, J. H.; MELLO, M. O; GALGARO, L.; TANAKA, A. S.; SILVA-FILHO, M. C.; NESHICH, G. Proteinase inhibition using small Bowman-Birk-type structures. Genetics and Molecular Research, v. 6, n. 4, p. 846-858, 2007.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 80. | | SANTOS, M. T.; FERRAZ, L. F. C.; REIS, F. C.; FALCÃO, P. R. K.; NESHICH, G.; OTTOBONI, L. M. M. Análise estrutural e funcional da proteína CMP quinase de Acidithiobacillus ferrooxidans. In: CONGRESSO BRASILEIRO DE GENÉTICA, 51., 2005, Águas de Lindóia. Resumos... Águas de Lindóias: SBG, 2005. p. 1075. Na publicação: Falcão, PK.| Biblioteca(s): Embrapa Agricultura Digital. |
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| Registros recuperados : 190 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agricultura Digital. Para informações adicionais entre em contato com cnptia.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Agricultura Digital. |
|
Data corrente: |
28/08/2007 |
|
Data da última atualização: |
17/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Circulação/Nível: |
Internacional - A |
|
Autoria: |
SIMÕES, M.; BAHIA, D.; ZERLOTINI, A.; TORRES, K.; ARTIGUENAVE, F.; NESHICH, G.; KUSER, P.; OLIVEIRA, G. |
|
Afiliação: |
MARIANA SIMÕES, Fiocruz; DIANA BAHIA, Fiocruz; ADHEMAR ZERLOTINI, Fiocruz; KLEIDER TORRES, Fiocruz; FRANÇOIS ARTIGUENAVE, Inra; GORAN NESHICH, CNPTIA; PAULA REGINA KUSER FALCAO, CNPTIA; GUILHERME OLIVEIRA, Fiocruz, Santa Casa de Belo Horizonte. |
|
Título: |
Single nucleotide polymorphisms identification in expressed genes of Schistosoma mansoni. |
|
Ano de publicação: |
2007 |
|
Fonte/Imprenta: |
Molecular and Biochemical Parasitology, v. 154, p. 134-140, 2007. |
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DOI: |
10.1016/j.molbiopara.2007.04.003 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Single nucleotide polymorphism (SNP) markers have been shown to be useful in genetic investigations of medically important parasites and their hosts. In this paper, we describe the prediction and validation of SNPs in ESTs of Schistosoma mansoni. We used 107,417 public sequences of S. mansoni and identified 15,614 high-quality candidate SNPs in 12,184 contigs. The presence of predicted SNPs was observed in well characterized antigens and vaccine candidates such as those coding for myosin; Sm14 and Sm23; cathepsin B and triosephosphate isomerase (TPI). Additionally, SNPs were experimentally validated for the cathepsin B. A comparative model of the S. mansoni cathepsin B was built for predicting the possible consequences of amino acid substitutions on the protein structure. An analysis of the substitutions indicated that the amino acids were mostly located on the surface of the molecule, and we found no evidence for a significant conformational change of the enzyme. However, at least one of the substitutions could result in a structural modification of an epitope |
|
Palavras-Chave: |
Bioinformática; Comparative modeling; Computational biology; Polimorfismo de nucleotídeo único. |
|
Thesagro: |
Schistosoma Mansoni. |
|
Thesaurus NAL: |
Bioinformatics; Cathepsin B; Models; Single nucleotide polymorphism. |
|
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
|
Marc: |
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001 1002699
005 2020-01-17
008 2007 bl uuuu u00u1 u #d
024 7 $a10.1016/j.molbiopara.2007.04.003$2DOI
100 1 $aSIMÕES, M.
245 $aSingle nucleotide polymorphisms identification in expressed genes of Schistosoma mansoni.$h[electronic resource]
260 $c2007
520 $aSingle nucleotide polymorphism (SNP) markers have been shown to be useful in genetic investigations of medically important parasites and their hosts. In this paper, we describe the prediction and validation of SNPs in ESTs of Schistosoma mansoni. We used 107,417 public sequences of S. mansoni and identified 15,614 high-quality candidate SNPs in 12,184 contigs. The presence of predicted SNPs was observed in well characterized antigens and vaccine candidates such as those coding for myosin; Sm14 and Sm23; cathepsin B and triosephosphate isomerase (TPI). Additionally, SNPs were experimentally validated for the cathepsin B. A comparative model of the S. mansoni cathepsin B was built for predicting the possible consequences of amino acid substitutions on the protein structure. An analysis of the substitutions indicated that the amino acids were mostly located on the surface of the molecule, and we found no evidence for a significant conformational change of the enzyme. However, at least one of the substitutions could result in a structural modification of an epitope
650 $aBioinformatics
650 $aCathepsin B
650 $aModels
650 $aSingle nucleotide polymorphism
650 $aSchistosoma Mansoni
653 $aBioinformática
653 $aComparative modeling
653 $aComputational biology
653 $aPolimorfismo de nucleotídeo único
700 1 $aBAHIA, D.
700 1 $aZERLOTINI, A.
700 1 $aTORRES, K.
700 1 $aARTIGUENAVE, F.
700 1 $aNESHICH, G.
700 1 $aKUSER, P.
700 1 $aOLIVEIRA, G.
773 $tMolecular and Biochemical Parasitology$gv. 154, p. 134-140, 2007.
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