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| 1. |  | RADEMAKER, V.; HERRERA, H. M.; RAFELL, T. R.; D' ANDREA, P. S.; FREITAS, T. P. T.; ABREU, U. G. P. de; HUDSON, P. J.; JANSEN, A. M. What is the role of small rodents in the transmission cycle of Trypanosoma cruzi and Trypanosoma evansi (Kinetoplastida Trypanosomatidae)? A study case in the Brazilian Pantanal. Acta Tropica, v.111, n.2, p.102-107, 2009. doi:10.1016/j.actatropica.2009.02.006.| Biblioteca(s): Embrapa Pantanal. |
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| 2. | | ALVES, F. M.; OLIFIERS, N.; BIANCHI, R. de C.; DUARTE, A. C.; COTIAS, P. M. T.; D´ANDREA, P. S.; GOMPPER, M. E.; MOURAO, G. de M.; HERRERA, H. M.; JANSEN, A. M. Modulating Variables of Trypanosoma cruzi and Trypanosoma evansi Transmission in Free-Ranging Coati (Nasua nasua) from the Brazilian Pantanal Region. Vector-Borne and Zoonotic Diseases, v. 11, n. 7, p. 835-841, 2011.| Biblioteca(s): Embrapa Pantanal. |
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| Registros recuperados : 2 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sul. Para informações adicionais entre em contato com cppsul.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
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Data corrente: |
17/10/2022 |
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Data da última atualização: |
10/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 1 |
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Autoria: |
PINHEIRO, N. B.; GASPAR, E. B.; MINHO, A. P.; DOMINGUES, R.; MOURA, M. Q. DE; VARELA JUNIOR, A. S.; CAPELLA, G. DE A.; STROTHMANN, A. L.; TERTO, W. D.; LEITE, F. P. L. |
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Afiliação: |
NATÁLIA BERNE PINHEIRO, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil; EMANUELLE BALDO GASPAR, CPPSUL; ALESSANDRO PELEGRINE MINHO, CPPSE; ROBERT DOMINGUES, CPPSUL; MICAELE QUINTANA DE MOURA, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil; ANTÔNIO SERGIO VARELA JUNIOR, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil; GABRIELA DE ALMEIDA CAPELLA, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil; ADRIANE LEITES STROTHMANN, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil; WESLEY DOUGLAS TERTO, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil; FABIO PEREIRA LEIVAS LEITE, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil. |
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Título: |
Sheep immune-stimulated with Saccharomyces boulardii show reduced prolificacy of Haemonchus contortus. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Parasite Immunology, v. 44, n. 12, e12954, Dec. 2022. |
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Páginas: |
6 p. |
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DOI: |
10.1111/pim.12954 |
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Idioma: |
Inglês |
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Conteúdo: |
Haemonchus contortus is the most pathogenic parasite for sheep. The objective was to evaluate immunomodulation of the probiotic Saccharomyces boulardii in sheep experimentally infected with H. contortus. Twenty-four sheep were divided into three groups: one infected with 500 H. contortus larvae/day for 26 days and supplemented with S. boulardii (40 ml with 1 × 108 CFU/ml/day); a control group only infected with H. contortus but not supplemented; and a naïve group that never came into contact with either parasites or S. boulardii. To assess the humoral immune response, production of specific serum IgG anti-somatic H. contortus antigen was evaluated through indirect ELISA. To assess the cellular immune response, cell populations and cytokine (IL-4, IL-5 and IL-10) production were evaluated through flow cytometry. For parasitological analyses, the counts of eggs per gram of faeces (EPG) and larvae per faecal culture were assessed. At all the study points, the concentration of IgG anti-H. contortus was higher (p < .05) in the S. boulardii group than in the other groups. The cell analysis revealed that there were significantly higher numbers (p < .05) of cells expressing MHC-II and significantly higher numbers (p < .05) of eosinophils in the mucosa in the S. boulardii group. Significant expression of IL-10 was observed only in the control infected group. There were significant reductions (p < .05) in EPG and larval counts in the S. boulardii supplemented group. These results show that S. boulardii supplementation modulated the immune response against H. contortus, thereby reducing its infection. MenosHaemonchus contortus is the most pathogenic parasite for sheep. The objective was to evaluate immunomodulation of the probiotic Saccharomyces boulardii in sheep experimentally infected with H. contortus. Twenty-four sheep were divided into three groups: one infected with 500 H. contortus larvae/day for 26 days and supplemented with S. boulardii (40 ml with 1 × 108 CFU/ml/day); a control group only infected with H. contortus but not supplemented; and a naïve group that never came into contact with either parasites or S. boulardii. To assess the humoral immune response, production of specific serum IgG anti-somatic H. contortus antigen was evaluated through indirect ELISA. To assess the cellular immune response, cell populations and cytokine (IL-4, IL-5 and IL-10) production were evaluated through flow cytometry. For parasitological analyses, the counts of eggs per gram of faeces (EPG) and larvae per faecal culture were assessed. At all the study points, the concentration of IgG anti-H. contortus was higher (p < .05) in the S. boulardii group than in the other groups. The cell analysis revealed that there were significantly higher numbers (p < .05) of cells expressing MHC-II and significantly higher numbers (p < .05) of eosinophils in the mucosa in the S. boulardii group. Significant expression of IL-10 was observed only in the control infected group. There were significant reductions (p < .05) in EPG and larval counts in the S. boulardii supplemented group. These results show... Mostrar Tudo |
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Palavras-Chave: |
Nematodes. |
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Thesagro: |
Controle Biológico; Fermento; Helminto; Nematóide; Ruminante. |
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Thesaurus NAL: |
Biological control; Helminths; Immune system; Probiotics; Ruminants; Yeasts. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02710naa a2200397 a 4500
001 2147342
005 2023-01-10
008 2022 bl uuuu u00u1 u #d
024 7 $a10.1111/pim.12954$2DOI
100 1 $aPINHEIRO, N. B.
245 $aSheep immune-stimulated with Saccharomyces boulardii show reduced prolificacy of Haemonchus contortus.$h[electronic resource]
260 $c2022
300 $a6 p.
520 $aHaemonchus contortus is the most pathogenic parasite for sheep. The objective was to evaluate immunomodulation of the probiotic Saccharomyces boulardii in sheep experimentally infected with H. contortus. Twenty-four sheep were divided into three groups: one infected with 500 H. contortus larvae/day for 26 days and supplemented with S. boulardii (40 ml with 1 × 108 CFU/ml/day); a control group only infected with H. contortus but not supplemented; and a naïve group that never came into contact with either parasites or S. boulardii. To assess the humoral immune response, production of specific serum IgG anti-somatic H. contortus antigen was evaluated through indirect ELISA. To assess the cellular immune response, cell populations and cytokine (IL-4, IL-5 and IL-10) production were evaluated through flow cytometry. For parasitological analyses, the counts of eggs per gram of faeces (EPG) and larvae per faecal culture were assessed. At all the study points, the concentration of IgG anti-H. contortus was higher (p < .05) in the S. boulardii group than in the other groups. The cell analysis revealed that there were significantly higher numbers (p < .05) of cells expressing MHC-II and significantly higher numbers (p < .05) of eosinophils in the mucosa in the S. boulardii group. Significant expression of IL-10 was observed only in the control infected group. There were significant reductions (p < .05) in EPG and larval counts in the S. boulardii supplemented group. These results show that S. boulardii supplementation modulated the immune response against H. contortus, thereby reducing its infection.
650 $aBiological control
650 $aHelminths
650 $aImmune system
650 $aProbiotics
650 $aRuminants
650 $aYeasts
650 $aControle Biológico
650 $aFermento
650 $aHelminto
650 $aNematóide
650 $aRuminante
653 $aNematodes
700 1 $aGASPAR, E. B.
700 1 $aMINHO, A. P.
700 1 $aDOMINGUES, R.
700 1 $aMOURA, M. Q. DE
700 1 $aVARELA JUNIOR, A. S.
700 1 $aCAPELLA, G. DE A.
700 1 $aSTROTHMANN, A. L.
700 1 $aTERTO, W. D.
700 1 $aLEITE, F. P. L.
773 $tParasite Immunology$gv. 44, n. 12, e12954, Dec. 2022.
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Embrapa Pecuária Sul (CPPSUL) |
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