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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Gado de Leite; Embrapa Pecuária Sudeste. |
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Data corrente: |
15/04/2014 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BUZANSKAS, M. E.; GROSSI, D. A.; VENTURA, R. V.; SCHENKEL, F. S.; SARGOLZAEI, M.; MEIRELLES, S. L. C. O; MOKRY, F. B.; HIGA, R. H.; MUDADU, M. de A.; SILVA, M. V. G. B.; NICIURA, S. C. M.; TORRES JUNIOR, R. A. de A.; ALENCAR, M. M. de; REGITANO, L. C. de A.; MUNARI, D. P. |
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Afiliação: |
MARCOS VINICIUS GUALBERTO B SILVA, CNPGL. |
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Título: |
Genome-wide association for growth traits in Canchim beef cattle. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Plos One, v. 9, n. 4, e94802 2014. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract. Studies are being conducted on the applicability of genomic data to improve the accuracy of the selection process in livestock, and genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to identify genomic regions and genes that play roles in birth weight (BW), weaning weight adjusted for 210 days of age (WW), and long-yearling weight adjusted for 420 days of age (LYW) in Canchim cattle. GWAS were performed by means of the Generalized Quasi-Likelihood Score (GQLS) method using genotypes from the BovineHD BeadChip and estimated breeding values for BW, WW, and LYW. Data consisted of 285 animals from the Canchim breed and 114 from the MA genetic group (derived from crossings between Charolais sires and 1/2 Canchim + 1/2 Zebu dams). After applying a false discovery rate correction at a 10% significance level, a total of 4, 12, and 10 SNPs were significantly associated with BW, WW, and LYW, respectively. These SNPs were surveyed to their corresponding genes or to surrounding genes within a distance of 250 kb. The genes DPP6 (dipeptidyl-peptidase 6) and CLEC3B (C-type lectin domain family 3 member B) were highlighted, considering its functions on the development of the brain and skeletal system, respectively. The GQLS method identified regions on chromosome associated with birth weight, weaning weight, and long-yearling weight in Canchim and MA animals. New candidate regions for body weight traits were detected and some of them have interesting biological functions, of which most have not been previously reported. The observation of QTL reports for body weight traits, covering areas surrounding the genes (SNPs) herein identified provides more evidence for these associations. Future studies targeting these areas could provide further knowledge to uncover the genetic architecture underlying growth traits in Canchim cattle. MenosAbstract. Studies are being conducted on the applicability of genomic data to improve the accuracy of the selection process in livestock, and genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to identify genomic regions and genes that play roles in birth weight (BW), weaning weight adjusted for 210 days of age (WW), and long-yearling weight adjusted for 420 days of age (LYW) in Canchim cattle. GWAS were performed by means of the Generalized Quasi-Likelihood Score (GQLS) method using genotypes from the BovineHD BeadChip and estimated breeding values for BW, WW, and LYW. Data consisted of 285 animals from the Canchim breed and 114 from the MA genetic group (derived from crossings between Charolais sires and 1/2 Canchim + 1/2 Zebu dams). After applying a false discovery rate correction at a 10% significance level, a total of 4, 12, and 10 SNPs were significantly associated with BW, WW, and LYW, respectively. These SNPs were surveyed to their corresponding genes or to surrounding genes within a distance of 250 kb. The genes DPP6 (dipeptidyl-peptidase 6) and CLEC3B (C-type lectin domain family 3 member B) were highlighted, considering its functions on the development of the brain and skeletal system, respectively. The GQLS method identified regions on chromosome associated with birth weight, weaning weight, and long-yearling weight in Canchim and MA animals. New candidate r... Mostrar Tudo |
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Palavras-Chave: |
Genome-wide; Growth trait; Raça Canchim; Race Canchim. |
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Thesagro: |
Gado de corte. |
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Thesaurus Nal: |
Beef cattle; genome-wide association study. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/105444/1/Artigo-MVinicius-journal.plosone.0094802.pdf
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/114268/1/Buzanskas2014-Genome.pdf
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/101136/1/PROCI-2014.00012.pdf
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Marc: |
LEADER 02995naa a2200373 a 4500
001 1986150
005 2024-02-05
008 2014 bl uuuu u00u1 u #d
100 1 $aBUZANSKAS, M. E.
245 $aGenome-wide association for growth traits in Canchim beef cattle.$h[electronic resource]
260 $c2014
520 $aAbstract. Studies are being conducted on the applicability of genomic data to improve the accuracy of the selection process in livestock, and genome-wide association studies (GWAS) provide valuable information to enhance the understanding on the genetics of complex traits. The aim of this study was to identify genomic regions and genes that play roles in birth weight (BW), weaning weight adjusted for 210 days of age (WW), and long-yearling weight adjusted for 420 days of age (LYW) in Canchim cattle. GWAS were performed by means of the Generalized Quasi-Likelihood Score (GQLS) method using genotypes from the BovineHD BeadChip and estimated breeding values for BW, WW, and LYW. Data consisted of 285 animals from the Canchim breed and 114 from the MA genetic group (derived from crossings between Charolais sires and 1/2 Canchim + 1/2 Zebu dams). After applying a false discovery rate correction at a 10% significance level, a total of 4, 12, and 10 SNPs were significantly associated with BW, WW, and LYW, respectively. These SNPs were surveyed to their corresponding genes or to surrounding genes within a distance of 250 kb. The genes DPP6 (dipeptidyl-peptidase 6) and CLEC3B (C-type lectin domain family 3 member B) were highlighted, considering its functions on the development of the brain and skeletal system, respectively. The GQLS method identified regions on chromosome associated with birth weight, weaning weight, and long-yearling weight in Canchim and MA animals. New candidate regions for body weight traits were detected and some of them have interesting biological functions, of which most have not been previously reported. The observation of QTL reports for body weight traits, covering areas surrounding the genes (SNPs) herein identified provides more evidence for these associations. Future studies targeting these areas could provide further knowledge to uncover the genetic architecture underlying growth traits in Canchim cattle.
650 $aBeef cattle
650 $agenome-wide association study
650 $aGado de corte
653 $aGenome-wide
653 $aGrowth trait
653 $aRaça Canchim
653 $aRace Canchim
700 1 $aGROSSI, D. A.
700 1 $aVENTURA, R. V.
700 1 $aSCHENKEL, F. S.
700 1 $aSARGOLZAEI, M.
700 1 $aMEIRELLES, S. L. C. O
700 1 $aMOKRY, F. B.
700 1 $aHIGA, R. H.
700 1 $aMUDADU, M. de A.
700 1 $aSILVA, M. V. G. B.
700 1 $aNICIURA, S. C. M.
700 1 $aTORRES JUNIOR, R. A. de A.
700 1 $aALENCAR, M. M. de
700 1 $aREGITANO, L. C. de A.
700 1 $aMUNARI, D. P.
773 $tPlos One$gv. 9, n. 4, e94802 2014.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Biblioteca |
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Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
20/04/2010 |
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Data da última atualização: |
16/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 1 |
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Autoria: |
ALVES, C. C. de S.; AZEVEDO, A. L. S.; RODRIGUES, M. F.; MACHADO, R. P.; SOUZA, M. A.; MACHADO, M. A.; TEIXEIRA, H. C.; FERREIRA, A. P. |
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Afiliação: |
CAIO CÉSAR DE SOUZA ALVES, UFJF; ANA LUISA SOUSA AZEVEDO, CNPGL; MICHELE F. RODRIGUES, UFJF; RACHEL P. MACHADO, UFJF; SUPREMA; MARIA A. SOUZA, UFJF; MARCO ANTONIO MACHADO, CNPGL; HENRIQUE C. TEIXEIRA, UFJF; ANA P. FERREIRA, UFJF. |
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Título: |
Cellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice. |
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Ano de publicação: |
2009 |
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Fonte/Imprenta: |
Comparative Immunology, Microbiology and Infectious Discases, v. 32, n. 6, p. 513-525, 2009. |
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DOI: |
https://doi.org/10.1016/j.cimid.2008.07.006 |
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Idioma: |
Inglês |
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Conteúdo: |
Paracoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-γ production was highest on day 15 p.i., declining thereafter. The kinetics of the NO production was similar to that described for IFN-γ. In contrast, IL-10 increased from day 45 p.i. reaching a peak at day 90. Levels of serum IgG1 were higher than IgG2a between days 30 and 90 p.i. 30% of mice died by day 90 p.i. These data indicate that infection with P. brasiliensis by the intrathoracic route shows high IFN-γ and NO production at day 15 p.i., unable to control multiplication of fungi, which appears to be associated with a progressive increase in IL-10 and in the number and complexity of granulomas. |
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Palavras-Chave: |
Antibody response; IFN-y; IL-10; Intrathoracic route. |
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Thesaurus NAL: |
Paracoccidioides brasiliensis. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/697051/1/Cellular-and-humoral-immune-responses-during-intrathoracic-paracoccidioidomycosis.pdf
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Marc: |
LEADER 01861naa a2200277 a 4500
001 1697051
005 2024-02-16
008 2009 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.cimid.2008.07.006$2DOI
100 1 $aALVES, C. C. de S.
245 $aCellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice.$h[electronic resource]
260 $c2009
520 $aParacoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-γ production was highest on day 15 p.i., declining thereafter. The kinetics of the NO production was similar to that described for IFN-γ. In contrast, IL-10 increased from day 45 p.i. reaching a peak at day 90. Levels of serum IgG1 were higher than IgG2a between days 30 and 90 p.i. 30% of mice died by day 90 p.i. These data indicate that infection with P. brasiliensis by the intrathoracic route shows high IFN-γ and NO production at day 15 p.i., unable to control multiplication of fungi, which appears to be associated with a progressive increase in IL-10 and in the number and complexity of granulomas.
650 $aParacoccidioides brasiliensis
653 $aAntibody response
653 $aIFN-y
653 $aIL-10
653 $aIntrathoracic route
700 1 $aAZEVEDO, A. L. S.
700 1 $aRODRIGUES, M. F.
700 1 $aMACHADO, R. P.
700 1 $aSOUZA, M. A.
700 1 $aMACHADO, M. A.
700 1 $aTEIXEIRA, H. C.
700 1 $aFERREIRA, A. P.
773 $tComparative Immunology, Microbiology and Infectious Discases$gv. 32, n. 6, p. 513-525, 2009.
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Embrapa Gado de Leite (CNPGL) |
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