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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
14/03/2024 |
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Data da última atualização: |
14/03/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ANDERSSON, E.; SCHULZ, R. W.; O'SULLIVAN, F. L. A.; KLEPPE, L.; SKAFTNESMO, K. O.; KJÆRNER-SEMB, E.; CRESPO, D.; FJELLDAL, P. G.; HANSEN, T. J.; NORBERG, B.; EDVARDSEN, R. B.; WARGELIUS, A. |
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Afiliação: |
EVA ANDERSSON, INSTITUTE OF MARINE RESEARCH; RÜDIGER W. SCHULZ, INSTITUTE OF MARINE RESEARCH; FERNANDA LOUREIRO ALMEIDA OSULLIVAN, CPAA; LENE KLEPPE, INSTITUTE OF MARINE RESEARCH; KAI OVE SKAFTNESMO, INSTITUTE OF MARINE RESEARCH; ERIK KJÆRNER-SEMB, INSTITUTE OF MARINE RESEARCH; DIEGO CRESPO, INSTITUTE OF MARINE RESEARCH; PER GUNNAR FJELLDAL, INSTITUTE OF MARINE RESEARCH; TOM JOHNNY HANSEN, INSTITUTE OF MARINE RESEARCH; BIRGITTA NORBERG, INSTITUTE OF MARINE RESEARCH; ROLF B. EDVARDSEN, INSTITUTE OF MARINE RESEARCH; ANNA WARGELIUS, INSTITUTE OF MARINE RESEARCH. |
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Título: |
Loss of fshr prevents testicular maturation in Atlantic Salmon (Salmo salar L.). |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Endocrinology, v. 165, n. 4, p. 1-14, 2024. |
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DOI: |
10.1210/endocr/bqae013 |
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Idioma: |
Inglês |
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Conteúdo: |
Early puberty poses a significant challenge for male Atlantic salmon in aquaculture due to its negative impact on growth and welfare. The regulation of puberty in vertebrates involves 2 key reproductive hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and their gonadal receptors. In male mice lacking FSH receptor, testes size is reduced, but fertility is maintained, while medaka and zebrafish with a disrupted fshr gene exhibit near normal testis size and fertility. In these fishes both Fsh and Lh are present during puberty and Lh may rescue fertility, while in salmonid fish only Fsh is present in the circulation during puberty. Using CRISPR-Cas9, we produced crispants with a high prevalence of fshr mutations at the target site, which remained fertile, although more than half showed a testis development deviating from wild-type (wt) males. |
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Palavras-Chave: |
Sterility. |
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Thesaurus Nal: |
Aquaculture; Puberty; Salmo salar. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1162834/1/bqae013.pdf
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Marc: |
LEADER 01737naa a2200313 a 4500
001 2162834
005 2024-03-14
008 2024 bl uuuu u00u1 u #d
024 7 $a10.1210/endocr/bqae013$2DOI
100 1 $aANDERSSON, E.
245 $aLoss of fshr prevents testicular maturation in Atlantic Salmon (Salmo salar L.).$h[electronic resource]
260 $c2024
520 $aEarly puberty poses a significant challenge for male Atlantic salmon in aquaculture due to its negative impact on growth and welfare. The regulation of puberty in vertebrates involves 2 key reproductive hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and their gonadal receptors. In male mice lacking FSH receptor, testes size is reduced, but fertility is maintained, while medaka and zebrafish with a disrupted fshr gene exhibit near normal testis size and fertility. In these fishes both Fsh and Lh are present during puberty and Lh may rescue fertility, while in salmonid fish only Fsh is present in the circulation during puberty. Using CRISPR-Cas9, we produced crispants with a high prevalence of fshr mutations at the target site, which remained fertile, although more than half showed a testis development deviating from wild-type (wt) males.
650 $aAquaculture
650 $aPuberty
650 $aSalmo salar
653 $aSterility
700 1 $aSCHULZ, R. W.
700 1 $aO'SULLIVAN, F. L. A.
700 1 $aKLEPPE, L.
700 1 $aSKAFTNESMO, K. O.
700 1 $aKJÆRNER-SEMB, E.
700 1 $aCRESPO, D.
700 1 $aFJELLDAL, P. G.
700 1 $aHANSEN, T. J.
700 1 $aNORBERG, B.
700 1 $aEDVARDSEN, R. B.
700 1 $aWARGELIUS, A.
773 $tEndocrinology$gv. 165, n. 4, p. 1-14, 2024.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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| 1. |  | ANDERSSON, E.; SCHULZ, R. W.; O'SULLIVAN, F. L. A.; KLEPPE, L.; SKAFTNESMO, K. O.; KJÆRNER-SEMB, E.; CRESPO, D.; FJELLDAL, P. G.; HANSEN, T. J.; NORBERG, B.; EDVARDSEN, R. B.; WARGELIUS, A. Loss of fshr prevents testicular maturation in Atlantic Salmon (Salmo salar L.). Endocrinology, v. 165, n. 4, p. 1-14, 2024.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| Registros recuperados : 1 | |
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