01737naa a2200313 a 450000100080000000500110000800800410001902400320006010000180009224501080011026000090021852008800022765000160110765000120112365000160113565300140115170000180116570000250118370000150120870000220122370000220124570000150126770000200128270000180130270000160132070000210133670000180135777300480137521628342024-03-14       2024    bl uuuu     u00u1 u    #d7 a10.1210/endocr/bqae0132DOI1 aANDERSSON, E.  aLoss of fshr prevents testicular maturation in Atlantic Salmon (Salmo salar L.).h[electronic resource]  c2024  aEarly puberty poses a significant challenge for male Atlantic salmon in aquaculture due to its negative impact on growth and welfare. The regulation of puberty in vertebrates involves 2 key reproductive hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and their gonadal receptors. In male mice lacking FSH receptor, testes size is reduced, but fertility is maintained, while medaka and zebrafish with a disrupted fshr gene exhibit near normal testis size and fertility. In these fishes both Fsh and Lh are present during puberty and Lh may rescue fertility, while in salmonid fish only Fsh is present in the circulation during puberty. Using CRISPR-Cas9, we produced crispants with a high prevalence of fshr mutations at the target site, which remained fertile, although more than half showed a testis development deviating from wild-type (wt) males.  aAquaculture  aPuberty  aSalmo salar  aSterility1 aSCHULZ, R. W.1 aO'SULLIVAN, F. L. A.1 aKLEPPE, L.1 aSKAFTNESMO, K. O.1 aKJÆRNER-SEMB, E.1 aCRESPO, D.1 aFJELLDAL, P. G.1 aHANSEN, T. J.1 aNORBERG, B.1 aEDVARDSEN, R. B.1 aWARGELIUS, A.  tEndocrinologygv. 165, n. 4, p. 1-14, 2024.