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Registro Completo |
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
08/10/2014 |
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Data da última atualização: |
06/03/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GASPAROTTO, J.; SOMENSI, N.; BORTOLIN, R. C.; GIRARDI, C. S.; KUNZLER, A.; RABELO, T. K.; SCHNORR, C. E.; MORESCO, K. Z.; BASSANI, V. L.; YATSU, F. K. J.; VIZZOTTO, M.; RASEIRA, M. do C. B.; ZANOTTO-FILHO, A.; MOREIRA, J. C. F.; GELAIN, D. P. |
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Afiliação: |
Juciano Gasparotto, UFRGS; Nauana Somensi; Rafael Calixto Bortolin; Carolina Saibro Girardi; Alice Kunzler; Thallita Kelly Rabelo; Carlos Eduardo Schnorr; Karla Suzana Moresco; Valquiria Linck Bassani; Francini Kiyono Jorge Yatsu; MARCIA VIZZOTTO, CPACT; MARIA DO CARMO BASSOLS RASEIRA, CPACT; Alfeu Zanotto-Filho; José Claudio Fonseca Moreira; Daniel Pens Gelain. |
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Título: |
Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
The Journal of Nutritional Biochemistry, v. 25, n. 12, p. 1282?1295, Dec. 2014. |
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DOI: |
doi:10.1016/j.jnutbio.2014.07.004 |
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Idioma: |
Inglês |
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Conteúdo: |
The present study was elaborated to comparatively evaluate the preventive effect of different peach-derived products obtained from preserved fruits (Syrup and Preserve Pulp Peach [PPP]) and from fresh peels and pulps (Peel and Fresh Pulp Peach [FPP]) in a model of liver/renal toxicity and inflammation induced by carbon tetrachloride (CCl4) in rats. Tissue damage (carbonyl, thiobarbituric acid reactive species and sulfhydril), antioxidant enzymes activity (catalase and superoxide dismutase) and inflammatory parameters [tumor necrosis factor (TNF)-? and interleukin (IL)-1? levels, and receptor for advanced glycation end-products (RAGE) and nuclear factor (NF)?B-p65 immunocontent] were investigated. Our findings demonstrated that Peel, PPP and FPP (200 or 400 mg/kg) daily administration by oral gavage for 30 days conferred a significant protection against CCl4-induced antioxidant enzymes activation and, most importantly, oxidative damage to lipids and proteins as well as blocked induction of inflammatory mediators such as TNF-?, IL-1?, RAGE and NF?B. This antioxidant/anti-inflammatory effect seems to be associated with the abundance of carotenoids and polyphenols present in peach-derived products, which are enriched in fresh-fruit-derived preparations (Peel and FPP) but are also present in PPP. The Syrup — which was the least enriched in antioxidants — displayed no protective effect in our experiments. These effects cumulated in decreased levels of transaminases and lactate dehydrogenase leakage into serum and maintenance of organ architecture. Therefore, the herein presented results show evidence that supplementation with peach products may be protective against organ damage caused by oxidative stress, being interesting candidates for production of antioxidant-enriched functional foods. MenosThe present study was elaborated to comparatively evaluate the preventive effect of different peach-derived products obtained from preserved fruits (Syrup and Preserve Pulp Peach [PPP]) and from fresh peels and pulps (Peel and Fresh Pulp Peach [FPP]) in a model of liver/renal toxicity and inflammation induced by carbon tetrachloride (CCl4) in rats. Tissue damage (carbonyl, thiobarbituric acid reactive species and sulfhydril), antioxidant enzymes activity (catalase and superoxide dismutase) and inflammatory parameters [tumor necrosis factor (TNF)-? and interleukin (IL)-1? levels, and receptor for advanced glycation end-products (RAGE) and nuclear factor (NF)?B-p65 immunocontent] were investigated. Our findings demonstrated that Peel, PPP and FPP (200 or 400 mg/kg) daily administration by oral gavage for 30 days conferred a significant protection against CCl4-induced antioxidant enzymes activation and, most importantly, oxidative damage to lipids and proteins as well as blocked induction of inflammatory mediators such as TNF-?, IL-1?, RAGE and NF?B. This antioxidant/anti-inflammatory effect seems to be associated with the abundance of carotenoids and polyphenols present in peach-derived products, which are enriched in fresh-fruit-derived preparations (Peel and FPP) but are also present in PPP. The Syrup — which was the least enriched in antioxidants — displayed no protective effect in our experiments. These effects cumulated in decreased levels of transaminases and lactate deh... Mostrar Tudo |
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Palavras-Chave: |
Anti-inflammatory; Antioxidant; NF?B-p65; Peach; RAGE. |
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Thesaurus Nal: |
carbon tetrachloride. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/109693/1/Marcia-Vizzotto-JournalofNutritionalBiochemistry2014.pdf
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Marc: |
LEADER 02937naa a2200373 a 4500
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024 7 $adoi:10.1016/j.jnutbio.2014.07.004$2DOI
100 1 $aGASPAROTTO, J.
245 $aPreventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage.$h[electronic resource]
260 $c2014
520 $aThe present study was elaborated to comparatively evaluate the preventive effect of different peach-derived products obtained from preserved fruits (Syrup and Preserve Pulp Peach [PPP]) and from fresh peels and pulps (Peel and Fresh Pulp Peach [FPP]) in a model of liver/renal toxicity and inflammation induced by carbon tetrachloride (CCl4) in rats. Tissue damage (carbonyl, thiobarbituric acid reactive species and sulfhydril), antioxidant enzymes activity (catalase and superoxide dismutase) and inflammatory parameters [tumor necrosis factor (TNF)-? and interleukin (IL)-1? levels, and receptor for advanced glycation end-products (RAGE) and nuclear factor (NF)?B-p65 immunocontent] were investigated. Our findings demonstrated that Peel, PPP and FPP (200 or 400 mg/kg) daily administration by oral gavage for 30 days conferred a significant protection against CCl4-induced antioxidant enzymes activation and, most importantly, oxidative damage to lipids and proteins as well as blocked induction of inflammatory mediators such as TNF-?, IL-1?, RAGE and NF?B. This antioxidant/anti-inflammatory effect seems to be associated with the abundance of carotenoids and polyphenols present in peach-derived products, which are enriched in fresh-fruit-derived preparations (Peel and FPP) but are also present in PPP. The Syrup — which was the least enriched in antioxidants — displayed no protective effect in our experiments. These effects cumulated in decreased levels of transaminases and lactate dehydrogenase leakage into serum and maintenance of organ architecture. Therefore, the herein presented results show evidence that supplementation with peach products may be protective against organ damage caused by oxidative stress, being interesting candidates for production of antioxidant-enriched functional foods.
650 $acarbon tetrachloride
653 $aAnti-inflammatory
653 $aAntioxidant
653 $aNF?B-p65
653 $aPeach
653 $aRAGE
700 1 $aSOMENSI, N.
700 1 $aBORTOLIN, R. C.
700 1 $aGIRARDI, C. S.
700 1 $aKUNZLER, A.
700 1 $aRABELO, T. K.
700 1 $aSCHNORR, C. E.
700 1 $aMORESCO, K. Z.
700 1 $aBASSANI, V. L.
700 1 $aYATSU, F. K. J.
700 1 $aVIZZOTTO, M.
700 1 $aRASEIRA, M. do C. B.
700 1 $aZANOTTO-FILHO, A.
700 1 $aMOREIRA, J. C. F.
700 1 $aGELAIN, D. P.
773 $tThe Journal of Nutritional Biochemistry$gv. 25, n. 12, p. 1282?1295, Dec. 2014.
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Registro original: |
Embrapa Clima Temperado (CPACT) |
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Registro Completo
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
27/09/2018 |
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Data da última atualização: |
17/12/2018 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
SILVA, V. M. da; MANRICH, A.; OTONI, C. G.; MATTOSO, L. H. C.; MARTINS, M. A. |
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Afiliação: |
LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA; MARIA ALICE MARTINS, CNPDIA. |
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Título: |
Extração e caracterização de cutina de maçã a partir de resíduos agroindustriais. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 10., 2018, São Carlos, SP. Anais... São Carlos: Embrapa Instrumentação: Embrapa Pecuária Sudeste, 2018. p. 68. Editores técnicos: Daniel Souza Corrêa, Elaine Cristina Paris, Maria Alice Martins, Paulino Ribeiro Villas Boas, Wilson Tadeu Lopes da Silva. (Embrapa Instrumentação. Documentos, 68). |
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Série: |
(Embrapa Instrumentação. Documentos, 68). |
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ISSN: |
1518-7179 |
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Idioma: |
Português |
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Palavras-Chave: |
Biopolímero; Cutina de maçã; Filmes; Resíduos agroindustriais. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/183590/1/Extracao-e-caracterizacao-de-cutina-de-maca-a-partir-de-residuos-agroindustriais..pdf
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Marc: |
LEADER 00990nam a2200217 a 4500
001 2096410
005 2018-12-17
008 2018 bl uuuu u00u1 u #d
022 $a1518-7179
100 1 $aSILVA, V. M. da
245 $aExtração e caracterização de cutina de maçã a partir de resíduos agroindustriais.$h[electronic resource]
260 $aIn: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 10., 2018, São Carlos, SP. Anais... São Carlos: Embrapa Instrumentação: Embrapa Pecuária Sudeste, 2018. p. 68. Editores técnicos: Daniel Souza Corrêa, Elaine Cristina Paris, Maria Alice Martins, Paulino Ribeiro Villas Boas, Wilson Tadeu Lopes da Silva. (Embrapa Instrumentação. Documentos, 68).$c2018
490 $a(Embrapa Instrumentação. Documentos, 68).
653 $aBiopolímero
653 $aCutina de maçã
653 $aFilmes
653 $aResíduos agroindustriais
700 1 $aMANRICH, A.
700 1 $aOTONI, C. G.
700 1 $aMATTOSO, L. H. C.
700 1 $aMARTINS, M. A.
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