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Registro Completo |
Biblioteca(s): |
Ebooks. |
Data corrente: |
01/02/2013 |
Data da última atualização: |
01/02/2013 |
Autoria: |
FALLON, P. G. |
Afiliação: |
Padraic G. Fallon. |
Título: |
Pathogen-Derived Immunomodulatory Molecules. |
Ano de publicação: |
2009 |
Fonte/Imprenta: |
Springer eBooks. |
Volume: |
666 |
Descrição Física: |
digital. |
Série: |
Advances in Experimental Medicine and Biology, |
ISBN: |
9781441916013 |
DOI: |
10.1007/978-1-4419-1601-3 |
Idioma: |
Inglês |
Conteúdo: |
Bacterial Toxins as Immunomodulators -- Innate Immune Evasion by Staphylococci -- Bacterial Complement Escape -- Modulation of Innate Immune Signalling Pathways by Viral Proteins -- Viral TNF Inhibitors as Potential Therapeutics -- Lipoxins as an Immune-Escape Mechanism -- Immunomodulatory Activity and Therapeutic Potential of the Filarial Nematode Secreted Product, ES-62 -- Helminth-derived imunomodulatory molecules -- Fungal-Derived Immune Modulating Molecules -- The Immunosuppresive Tick Salivary Protein, Salp15 -- The Serpin Saga; Development of a New Class of Virus Derived Anti-inflamatory Protein Immunotherapeutics -- Helminthic Therapy: Using Worms to Treat Immune-Mediated Disease -- Chemokine Binding Proteins Encoded by Pathogens. .Pathogen-Derived Immunomodulatory Molecules is a book title that may require some explanation. Pathogens that are present today have evolved following a long association with man and have developed unique strategies that have been optimized by natural selection to subvert the host immunity. As we approach the 200th anniversary of Charles Darwin’s birth, it is appropriate to appreciate that Darwin recognized that pathogens (infections) play a significant and potent role in natural selection, encompassed by the concept “infection begets natural selection”. This book therefore examines the molecules that pathogens produce, which can modulate or usurp the functions of the immune system. The idea of using molecules from pathogens as a therapeutic is an ancient concept in medicine. Such a strategy is exemplified by vaccination, with pathogen molecules employed to induce protective immunity against the given or related species of pathogen. The following chapters explore the concept of using pathogen-derived immune modulating molecules as a therapy. In doing so, they may provide the drug cabinet of the future for treating a spectrum of unrelated disease. Herein, a range of immune modulating molecules or strategies from various pathogens is examined in one volume. The intention of the book was to have chapters addressing immunomodulating molecules from different pathogens. The range of pathogens considered includes bacteria (chapters by Williams, van Strijp and Rooijakkers), viruses (chapters by Bowie, McFadden), protozoan parasites (Aliberti), helminths (Harnett, Fallon), fungi (Sorrell) and parasitic ticks (Anguita). Chapters also address specific immunomodulatory molecules or strategies. The diversity of aspects addressed in the book is highlighted by Lucas and colleagues review of the ‘saga’ of viral serine proteinase inhibitors, with a focus on Serp-1, the first new generation of pathogen immunomodulatory molecule currently in clinical trials. While Elliott and Weinstock have contributed a provocative chapter exploring the use of live parasitic helminth infections as a therapeutic strategy for immune-mediated diseases; indeed trials have already been completed for such an approach. With respect to pathogens usurping an immune pathway, Alcami and colleagues here reviewed the growing number of pathogens that have evolved a range of molecules that can modify many aspects of the chemokine system. This book is timely due to the need to expand the horizons of conventional drug discovery. A trend in the biopharmaceutical pipeline of fewer drugs to market is illustrated by USA FDA in 2007 approving the lowest number of new molecular entities since 1983. As the drug discovery and development industry broadens its search for new drugs to less traditional strategies, this book will be a reference to the potential for exploiting pathogen as a source of the anti-inflammatory drugs of the future. Finally, this book whets the appetite for the reader, whether in academia or industry, to explore opportunities for exploiting pathogens for the discovery of new processes in immunobiology and, ultimately, for development of new therapies for human inflammatory diseases. MenosBacterial Toxins as Immunomodulators -- Innate Immune Evasion by Staphylococci -- Bacterial Complement Escape -- Modulation of Innate Immune Signalling Pathways by Viral Proteins -- Viral TNF Inhibitors as Potential Therapeutics -- Lipoxins as an Immune-Escape Mechanism -- Immunomodulatory Activity and Therapeutic Potential of the Filarial Nematode Secreted Product, ES-62 -- Helminth-derived imunomodulatory molecules -- Fungal-Derived Immune Modulating Molecules -- The Immunosuppresive Tick Salivary Protein, Salp15 -- The Serpin Saga; Development of a New Class of Virus Derived Anti-inflamatory Protein Immunotherapeutics -- Helminthic Therapy: Using Worms to Treat Immune-Mediated Disease -- Chemokine Binding Proteins Encoded by Pathogens. .Pathogen-Derived Immunomodulatory Molecules is a book title that may require some explanation. Pathogens that are present today have evolved following a long association with man and have developed unique strategies that have been optimized by natural selection to subvert the host immunity. As we approach the 200th anniversary of Charles Darwin’s birth, it is appropriate to appreciate that Darwin recognized that pathogens (infections) play a significant and potent role in natural selection, encompassed by the concept “infection begets natural selection”. This book therefore examines the molecules that pathogens produce, which can modulate or usurp the functions of the immune system. The idea of using molecules from... Mostrar Tudo |
Palavras-Chave: |
Biomedicine; Biomedicine general. |
Thesaurus Nal: |
medicine. |
Categoria do assunto: |
-- |
URL: |
https://dx.doi.org/10.1007/978-1-4419-1601-3
|
Marc: |
LEADER 04625nam a2200193 a 4500 001 1947390 005 2013-02-01 008 2009 bl uuuu u0uu1 u #d 020 $a9781441916013 024 7 $a10.1007/978-1-4419-1601-3$2DOI 100 1 $aFALLON, P. G. 245 $aPathogen-Derived Immunomodulatory Molecules.$h[electronic resource] 260 $aSpringer eBooks.$c2009 300 $a666$cdigital. 490 $aAdvances in Experimental Medicine and Biology,$v666 520 $a<P>Bacterial Toxins as Immunomodulators -- Innate Immune Evasion by Staphylococci -- Bacterial Complement Escape -- Modulation of Innate Immune Signalling Pathways by Viral Proteins -- Viral TNF Inhibitors as Potential Therapeutics -- Lipoxins as an Immune-Escape Mechanism -- Immunomodulatory Activity and Therapeutic Potential of the Filarial Nematode Secreted Product, ES-62 -- Helminth-derived imunomodulatory molecules -- Fungal-Derived Immune Modulating Molecules -- The Immunosuppresive Tick Salivary Protein, Salp15 -- The Serpin Saga; Development of a New Class of Virus Derived Anti-inflamatory Protein Immunotherapeutics -- Helminthic Therapy: Using Worms to Treat Immune-Mediated Disease -- Chemokine Binding Proteins Encoded by Pathogens.</P>.<P><EM>Pathogen-Derived Immunomodulatory Molecules</EM> is a book title that may require some explanation. Pathogens that are present today have evolved following a long association with man and have developed unique strategies that have been optimized by natural selection to subvert the host immunity. As we approach the 200th anniversary of Charles Darwin’s birth, it is appropriate to appreciate that Darwin recognized that pathogens (infections) play a significant and potent role in natural selection, encompassed by the concept “infection begets natural selection”. This book therefore examines the molecules that pathogens produce, which can modulate or usurp the functions of the immune system.</P> <P>The idea of using molecules from pathogens as a therapeutic is an ancient concept in medicine. Such a strategy is exemplified by vaccination, with pathogen molecules employed to induce protective immunity against the given or related species of pathogen. The following chapters explore the concept of using pathogen-derived immune modulating molecules as a therapy. In doing so, they may provide the drug cabinet of the future for treating a spectrum of unrelated disease. Herein, a range of immune modulating molecules or strategies from various pathogens is examined in one volume.</P> <P>The intention of the book was to have chapters addressing immunomodulating molecules from different pathogens. The range of pathogens considered includes bacteria (chapters by Williams, van Strijp and Rooijakkers), viruses (chapters by Bowie, McFadden), protozoan parasites (Aliberti), helminths (Harnett, Fallon), fungi (Sorrell) and parasitic ticks (Anguita). Chapters also address specific immunomodulatory molecules or strategies. The diversity of aspects addressed in the book is highlighted by Lucas and colleagues review of the ‘saga’ of viral serine proteinase inhibitors, with a focus on Serp-1, the first new generation of pathogen immunomodulatory molecule currently in clinical trials. While Elliott and Weinstock have contributed a provocative chapter exploring the use of live parasitic helminth infections as a therapeutic strategy for immune-mediated diseases; indeed trials have already been completed for such an approach. With respect to pathogens usurping an immune pathway, Alcami and colleagues here reviewed the growing number of pathogens that have evolved a range of molecules that can modify many aspects of the chemokine system.</P> <P>This book is timely due to the need to expand the horizons of conventional drug discovery. A trend in the biopharmaceutical pipeline of fewer drugs to market is illustrated by USA FDA in 2007 approving the lowest number of new molecular entities since 1983. As the drug discovery and development industry broadens its search for new drugs to less traditional strategies, this book will be a reference to the potential for exploiting pathogen as a source of the anti-inflammatory drugs of the future.</P> <P>Finally, this book whets the appetite for the reader, whether in academia or industry, to explore opportunities for exploiting pathogens for the discovery of new processes in immunobiology and, ultimately, for development of new therapies for human inflammatory diseases.</P> 650 $amedicine 653 $aBiomedicine 653 $aBiomedicine general
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Registro Completo
Biblioteca(s): |
Embrapa Uva e Vinho. |
Data corrente: |
03/03/2017 |
Data da última atualização: |
08/03/2019 |
Tipo da produção científica: |
Artigo de Divulgação na Mídia |
Autoria: |
BRUNETTO, G.; CERETTA, C. A.; FERREIRA, P. A. A.; COUTO, R. R.; SILVA, L. O. S; DE CONTI, L.; MELO, G. W. B. de; ZALAMENA, J; COMIN, J. J.; LOURENZI, C. R.; AMBROSINI, V. G; GIROTTO, E.; GATIBONI, L. C. |
Afiliação: |
Gustavo Brunetto, Engenheiro Agrônomo, Doutor, Professor Universidade Federal de Santa Maria/Bolsista em Produtividade do CNPq brunetto.gustavo@gmail.com; Carlos Alberto Ceretta, Engenheiro Agrônomo, Doutor, Professor Universidade Federal de Santa Maria/Bolsista em Produtividade do CNPq carlosceretta@gmail.com; Paulo Ademar Avelar Ferreira, Engenheiro Agrônomo, Pós-Doutorando Universidade Federal de Santa Maria avelarufla@gmail.com; Rafael Rosa Couto, Engenheiro Agrônomo, Pós-Doutorando Universidade Federal de Santa Maria rrcouto@hotmail.com; Lessandro De Conti, Engenheiro Agrônomo, Doutorando Universidade Federal de Santa Maria lessandrodeconti@gmail.com; GEORGE WELLINGTON BASTOS DE MELO, CNPUV; Jovani Zalamena, Engenheiro Agrônomo, Pós-Doutorando Universidade Federal de Santa Maria jovanizalamena@yahoo.com.br; Jucinei José Comin, Engenheiro Agrônomo, Doutor, Professor Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul girottosolos@gmail.com; Cledimar Rogério Lourenzi, Engenheiro Agrônomo, Doutor, Professor Universidade Federal de Santa Catarina lourenzicr@gmail.com; Vítor Gabriel Ambrosini, Engenheiro Agrônomo, Doutorando Universidade Federal do Rio Grande do Sul vgambrosini@gmail.com; Eduardo Girotto, Engenheiro Agrônomo, Doutor, Professor Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul eduardo.girotto@ibiruba.ifrs.edu.br; girottosolos@gmail.com; Luciano Colpo Gatiboni, Engenheiro Agrônomo, Doutor, Professor Universidade do Estado de Santa Catarina lgatiboni@gmail.com. |
Título: |
Gestão da fertilização azotada na vinha. |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
ENOVITIS - Revista Técnica de Viticultura e Enologia, p. 20 - 21, 01 jan. 2016. |
Idioma: |
Português |
Conteúdo: |
Solos arenosos e com baixo teor de matéria orgânica cultivados com videiras podem não disponibilizar a quantidade de azoto(N) necessária para suprir as necessidades das plantas. Assim, torna-se necessário para suprir as necessidades das plantas. Assim, torna-se necessário a aplicação de N na vinha, quer com fertilizantes |
Palavras-Chave: |
Azoto; Solos arenosos; Videira. |
Thesagro: |
Matéria Orgânica; Vinho. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/157627/1/George-Artigo-Portugal.pdf
|
Marc: |
LEADER 01187nam a2200313 a 4500 001 2065896 005 2019-03-08 008 2016 bl uuuu u00u1 u #d 100 1 $aBRUNETTO, G. 245 $aGestão da fertilização azotada na vinha.$h[electronic resource] 260 $aENOVITIS - Revista Técnica de Viticultura e Enologia, p. 20 - 21, 01 jan. 2016.$c2016 520 $aSolos arenosos e com baixo teor de matéria orgânica cultivados com videiras podem não disponibilizar a quantidade de azoto(N) necessária para suprir as necessidades das plantas. Assim, torna-se necessário para suprir as necessidades das plantas. Assim, torna-se necessário a aplicação de N na vinha, quer com fertilizantes 650 $aMatéria Orgânica 650 $aVinho 653 $aAzoto 653 $aSolos arenosos 653 $aVideira 700 1 $aCERETTA, C. A. 700 1 $aFERREIRA, P. A. A. 700 1 $aCOUTO, R. R. 700 1 $aSILVA, L. O. S 700 1 $aDE CONTI, L. 700 1 $aMELO, G. W. B. de 700 1 $aZALAMENA, J 700 1 $aCOMIN, J. J. 700 1 $aLOURENZI, C. R. 700 1 $aAMBROSINI, V. G 700 1 $aGIROTTO, E. 700 1 $aGATIBONI, L. C
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