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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
21/08/2021 |
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Data da última atualização: |
21/08/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, N. P. da; PEREIRA, E. do C. R. L.; DUARTE, L. M.; FREITAS, J. C. de O.; ALMEIDA, C. G. de; SILVA, T. P. da; MELO, R. C. N.; APOLONIO, A. C. M.; OLIVEIRA, M. A. L. de; BRANDAO, H. de M.; PITTELLA, F.; FABRI, R. L.; TAVARES, G. D.; PINTO, P. de F. |
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Afiliação: |
NATALIA PRADO DA SILVA, Universidade Federal de Juiz de Fora; ELOA DO CARMO RAPOZO LAVINAS PEREIRA, Universidade Federal de Juiz de Fora; LUCAS MATTOS DUARTE, Universidade Federal de Juiz de Fora; JHAMINE CAROLINE DE OLIVEIRA FREITAS, Universidade Federal de Juiz de Fora; CAMILA GUIMARAES DE ALMEIDA; THIAGO PEREIRA DA SILVA, Universidade Federal de Juiz de Fora; ROSSANA C. N. MELO, Universidade Federal de Juiz de Fora; ANA CAROLINA MORAIS APOLONIO, Universidade Federal de Juiz de Fora; MARCONE AUGUSTO LEAL DE OLIVEIRA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; FREDERICO PITTELLA, Universidade Federal de Juiz de Fora; RODRIGO LUIZ FABRI, Universidade Federal de Juiz de Fora; GUILHERME DINIZ TAVARES, Universidade Federal de Juiz de Fora; PRISCILA DE FARIA PINTO, Universidade Federal de Juiz de Fora. |
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Título: |
Improved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Colloids and Surfaces B: Biointerfaces, v. 196, 111371, 2020. |
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DOI: |
https://doi.org/10.1016/j.colsurfb.2020.111371 |
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Idioma: |
Inglês |
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Conteúdo: |
The purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore, chitosan-poly(?-caprolactone) core-shell nanocapsules are a promising tool for TTO delivery, aiming at the activity against C. acnes for the topical acne treatment. MenosThe purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore... Mostrar Tudo |
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Palavras-Chave: |
Acne vulgaris; Core-shell nanocapsules; Nanocápsula; Quitosana-poli. |
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Thesagro: |
Árvore. |
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Thesaurus Nal: |
Chitosan; Tea tree oil. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 02808naa a2200373 a 4500
001 2133785
005 2021-08-21
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.colsurfb.2020.111371$2DOI
100 1 $aSILVA, N. P. da
245 $aImproved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules.$h[electronic resource]
260 $c2020
520 $aThe purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore, chitosan-poly(?-caprolactone) core-shell nanocapsules are a promising tool for TTO delivery, aiming at the activity against C. acnes for the topical acne treatment.
650 $aChitosan
650 $aTea tree oil
650 $aÁrvore
653 $aAcne vulgaris
653 $aCore-shell nanocapsules
653 $aNanocápsula
653 $aQuitosana-poli
700 1 $aPEREIRA, E. do C. R. L.
700 1 $aDUARTE, L. M.
700 1 $aFREITAS, J. C. de O.
700 1 $aALMEIDA, C. G. de
700 1 $aSILVA, T. P. da
700 1 $aMELO, R. C. N.
700 1 $aAPOLONIO, A. C. M.
700 1 $aOLIVEIRA, M. A. L. de
700 1 $aBRANDAO, H. de M.
700 1 $aPITTELLA, F.
700 1 $aFABRI, R. L.
700 1 $aTAVARES, G. D.
700 1 $aPINTO, P. de F.
773 $tColloids and Surfaces B: Biointerfaces$gv. 196, 111371, 2020.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 64 | |
| 61. |  | ROCHA, S. K. da S.; AMABILE, R. F.; THOMÉ, R. D.; RAMOS, S. D. R.; SALA, P. I. A. L.; BRIGE, F. A. A.; CARVALHO, C. G. P.; LOURES, L. M. R.; CARVALHO, I. A. de; SILVA, T. P. da; ARTIAGA, I. F.; VIEIRA, W. F. DIVERSIDADE GENÉTICA EM GENÓTIPOS DE GIRASSOL NO CERRADO DO PLANALTO CENTRAL. GENETIC DIVERSITY IN SUNFLOWER GENOTYPES IN THE BRAZILIAN SAVANNA AT PLANALTO CENTRAL. In: REUNIÃO NACIONAL DE PESQUISA DE GIRASSOL, 23.; SIMPÓSIO NACIONAL SOBRE A CULTURA DO GIRASSOL, 11., 2020, Londrina. Anais... Londrina: Embrapa Soja, 2020. (Embrapa Soja. Documentos, 432). Editado por Regina Maria Villas Bôas de Campos Leite, Hugo Soares Kern. p. 110-112 (Embrapa Soja. Documentos, 432). Artigo de acesso aberto.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Cerrados. |
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| 62. | | ROCHA, S. K. da S.; AMABILE, R. F.; THOMÉ, R. D.; RAMOS, S. D. R.; SALA, P. I. A. L.; BRIGE, F. A. A.; CARVALHO, C. G. P.; LOURES, L. M. R.; CARVALHO, I. A. de; SILVA, T. P. da; ARTIAGA, I. F.; VIEIRA, W. F. DIVERSIDADE GENÉTICA EM GENÓTIPOS DE GIRASSOL NO CERRADO DO PLANALTO CENTRAL. GENETIC DIVERSITY IN SUNFLOWER GENOTYPES IN THE BRAZILIAN SAVANNA AT PLANALTO CENTRAL. In: REUNIÃO NACIONAL DE PESQUISA DE GIRASSOL, 23.; SIMPÓSIO NACIONAL SOBRE A CULTURA DO GIRASSOL, 11., 2020, Londrina. Anais... Londrina: Embrapa Soja, 2020. p. 110-112. (Embrapa Soja. Documentos, 432). Editado por Regina Maria Villas Bôas de Campos Leite, Hugo Soares Kern. Artigo de acesso aberto.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Soja. |
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| 63. | | SILVA, N. P. da; PEREIRA, E. do C. R. L.; DUARTE, L. M.; FREITAS, J. C. de O.; ALMEIDA, C. G. de; SILVA, T. P. da; MELO, R. C. N.; APOLONIO, A. C. M.; OLIVEIRA, M. A. L. de; BRANDAO, H. de M.; PITTELLA, F.; FABRI, R. L.; TAVARES, G. D.; PINTO, P. de F. Improved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules. Colloids and Surfaces B: Biointerfaces, v. 196, 111371, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 64. | | CARVALHO, I. A.; DINIZ, W. B.; RAMOS, S. D. R.; BRIGE, F. A. A.; MALAQUIAS, J. V.; SALA, P. I. A. L.; AMABILE, R. F.; ROCHA, S. K.; LOURES, L. M. R.; SILVA, T. P.; VIEIRA, W. F.; CARVALHO, C. G. P. Variabilidade genética entre genótipos de girassol no Planalto Central. In: SIMPÓSIO DE MELHORAMENTO DE PLANTAS, 3., 2020. O melhoramento sem fronteiras. Brasília, DF: SBMP, 2020.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Cerrados. |
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| Registros recuperados : 64 | |
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