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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
21/11/2023 |
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Data da última atualização: |
21/11/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GOUVEIA, G. C.; RIBEIRO, V. M. P.; FORTES, M. R. S.; RAIDAN, F. S. S.; REVERTER, A.; PORTO-NETO, L. R.; MORAES, M. M. de; GONÇALVES, D. R.; SILVA, M. V. G. B.; TORAL, F. L. B. |
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Afiliação: |
GABRIELA CANABRAVA GOUVEIA, UNIVERSIDADE FEDERAL DE MINAS GERAIS; VIRGÍNIA MARA PEREIRA RIBEIRO, UNIVERSIDADE FEDERAL DE MINAS GERAIS; MARINA RUFINO SALINAS FORTES, UNIVERSITY OF QUEENSLAND; FERNANDA SANTOS SILVA RAIDAN, CSIRO; ANTONIO REVERTER, CSIRO; LAERCIO RIBEIRO PORTO‑NETO, CSIRO; MARIANA MAMEDES DE MORAES, UNIVERSIDADE FEDERAL DE MINAS GERAIS; DANIEL RESENDE GONÇALVES, MUNDO NOVO FARM; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; FABIO LUIZ BURANELO TORAL, UNIVERSIDADE FEDERAL DE MINAS GERAIS. |
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Título: |
Unravelling the genetic variability of host resilience to endo and ectoparasites in Nellore commercial herds. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Genetics Selection Evolution, v. 55, article 81, 2023. |
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Idioma: |
Inglês |
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Conteúdo: |
BACKGROUND- Host resilience (HR) to parasites can afect the performance of animals. Therefore, the aim of this study was to present a detailed investigation of the genetic mechanisms of HR to ticks (TICK), gastrointestinal nematodes (GIN), and Eimeria spp. (EIM) in Nellore cattle that were raised under natural infestation and a prophylactic parasite control strategy. In our study, HR was defned as the slope coefcient of body weight (BW) when TICK, GIN, and EIM burdens were used as environmental gradients in random regression models. In total, 1712 animals were evaluated at fve measurement events (ME) at an average age of 331, 385, 443, 498, and 555 days, which generated 7307 body weight (BW) records. Of the 1712 animals, 1075 genotyped animals were used in genome-wide association studies to identify genomic regions associated with HR. RESULTS- Posterior means of the heritability estimates for BW ranged from 0.09 to 0.54 across parasites and ME. The single nucleotide polymorphism (SNP)-derived heritability for BW at each ME ranged from a low (0.09 at ME.331) to a moderate value (0.23 at ME.555). Those estimates show that genetic progress can be achieved for BW through selection. Both genetic and genomic associations between BW and HR to TICK, GIN, and EIM confrmed that parasite infestation impacted the performance of animals. Selection for BW under an environment with a controlled parasite burden is an alternative to improve both, BW and HR. There was no impact of age of measurement on the estimates of genetic variance for HR. Five quantitative trait loci (QTL) were associated with HR to EIM but none with HR to TICK and to GIN. These QTL contain genes that were previously shown to be associated with the production of antibody modulators and chemokines that are released in the intestinal epithelium. CONCLUSIONS- Selection for BW under natural infestation and controlled parasite burden, via prophylactic parasite control, contributes to the identifcation of animals that are resilient to nematodes and Eimeria ssp. Although we verifIed that sufcient genetic variation existed for HR, we did not fnd any genes associated with mechanisms that could justify the expression of HR to TICK and GIN. MenosBACKGROUND- Host resilience (HR) to parasites can afect the performance of animals. Therefore, the aim of this study was to present a detailed investigation of the genetic mechanisms of HR to ticks (TICK), gastrointestinal nematodes (GIN), and Eimeria spp. (EIM) in Nellore cattle that were raised under natural infestation and a prophylactic parasite control strategy. In our study, HR was defned as the slope coefcient of body weight (BW) when TICK, GIN, and EIM burdens were used as environmental gradients in random regression models. In total, 1712 animals were evaluated at fve measurement events (ME) at an average age of 331, 385, 443, 498, and 555 days, which generated 7307 body weight (BW) records. Of the 1712 animals, 1075 genotyped animals were used in genome-wide association studies to identify genomic regions associated with HR. RESULTS- Posterior means of the heritability estimates for BW ranged from 0.09 to 0.54 across parasites and ME. The single nucleotide polymorphism (SNP)-derived heritability for BW at each ME ranged from a low (0.09 at ME.331) to a moderate value (0.23 at ME.555). Those estimates show that genetic progress can be achieved for BW through selection. Both genetic and genomic associations between BW and HR to TICK, GIN, and EIM confrmed that parasite infestation impacted the performance of animals. Selection for BW under an environment with a controlled parasite burden is an alternative to improve both, BW and HR. There was no impact of age of meas... Mostrar Tudo |
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Palavras-Chave: |
Variabilidade genética. |
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Thesagro: |
Bovino; Gado Nelore; Hospedeiro Animal; Parasito de Animal. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1158625/1/Unravelling-the-genetic-variability-of-host-resilience-to-endo-and-ectoparasites-in-Nellore.pdf
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Marc: |
LEADER 03090naa a2200289 a 4500
001 2158625
005 2023-11-21
008 2023 bl uuuu u00u1 u #d
100 1 $aGOUVEIA, G. C.
245 $aUnravelling the genetic variability of host resilience to endo and ectoparasites in Nellore commercial herds.$h[electronic resource]
260 $c2023
520 $aBACKGROUND- Host resilience (HR) to parasites can afect the performance of animals. Therefore, the aim of this study was to present a detailed investigation of the genetic mechanisms of HR to ticks (TICK), gastrointestinal nematodes (GIN), and Eimeria spp. (EIM) in Nellore cattle that were raised under natural infestation and a prophylactic parasite control strategy. In our study, HR was defned as the slope coefcient of body weight (BW) when TICK, GIN, and EIM burdens were used as environmental gradients in random regression models. In total, 1712 animals were evaluated at fve measurement events (ME) at an average age of 331, 385, 443, 498, and 555 days, which generated 7307 body weight (BW) records. Of the 1712 animals, 1075 genotyped animals were used in genome-wide association studies to identify genomic regions associated with HR. RESULTS- Posterior means of the heritability estimates for BW ranged from 0.09 to 0.54 across parasites and ME. The single nucleotide polymorphism (SNP)-derived heritability for BW at each ME ranged from a low (0.09 at ME.331) to a moderate value (0.23 at ME.555). Those estimates show that genetic progress can be achieved for BW through selection. Both genetic and genomic associations between BW and HR to TICK, GIN, and EIM confrmed that parasite infestation impacted the performance of animals. Selection for BW under an environment with a controlled parasite burden is an alternative to improve both, BW and HR. There was no impact of age of measurement on the estimates of genetic variance for HR. Five quantitative trait loci (QTL) were associated with HR to EIM but none with HR to TICK and to GIN. These QTL contain genes that were previously shown to be associated with the production of antibody modulators and chemokines that are released in the intestinal epithelium. CONCLUSIONS- Selection for BW under natural infestation and controlled parasite burden, via prophylactic parasite control, contributes to the identifcation of animals that are resilient to nematodes and Eimeria ssp. Although we verifIed that sufcient genetic variation existed for HR, we did not fnd any genes associated with mechanisms that could justify the expression of HR to TICK and GIN.
650 $aBovino
650 $aGado Nelore
650 $aHospedeiro Animal
650 $aParasito de Animal
653 $aVariabilidade genética
700 1 $aRIBEIRO, V. M. P.
700 1 $aFORTES, M. R. S.
700 1 $aRAIDAN, F. S. S.
700 1 $aREVERTER, A.
700 1 $aPORTO-NETO, L. R.
700 1 $aMORAES, M. M. de
700 1 $aGONÇALVES, D. R.
700 1 $aSILVA, M. V. G. B.
700 1 $aTORAL, F. L. B.
773 $tGenetics Selection Evolution$gv. 55, article 81, 2023.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
08/02/2002 |
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Data da última atualização: |
10/02/2020 |
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Autoria: |
ROCHA, H. V. da; OEIRAS, J. Y. Y.; FREIRE, F. M. P.; ROMANI, L. A. S. |
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Afiliação: |
HELOÍSA VIEIRA DA ROCHA, IC/Unicamp; JANNE YUKIKO Y. OEIRAS, IC/Unicamp; FERNANDA MARIA PEREIRA FREIRE, Nied/Unicamp; LUCIANA ALVIM SANTOS ROMANI, CNPTIA. |
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Título: |
Design de ambientes para EaD: (re) significações do usuário. |
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Ano de publicação: |
2001 |
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Fonte/Imprenta: |
In: WORKSHOP SOBRE FATORES HUMANOS EM SISTEMAS COMPUTACIONAIS, 4., 2001, Florianópolis. Anais... Florianópolis: UFSC/SBC, 2001. |
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Páginas: |
p. 84-95. |
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ISBN: |
85-88442-09-4 |
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Idioma: |
Português |
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Notas: |
IHC 2001. |
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Conteúdo: |
Este trabalho descreve e discute alguns dados relacionados ao uso alternativo de algumas ferramentas do ambiente TelEduc para EaD, coletados no decorrer de vários cursos a distância. A análise dos dados indica que os usuários reinterpretam as intenções do designer desenvolvendo um modelo muitas vezes distante do modelo conceitual do design do ambiente. E, de certa forma contraditoriamente aos resultados da área de IHC, esta possibilidade de múltiplas reinterpretações por parte do usuário é desejável, considerando-se a tarefa de educar a distância. |
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Palavras-Chave: |
Design de ambientes; Educação à distância; TelEduc. |
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Thesaurus NAL: |
Distance education; Learning. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/183411/1/PL-Design-IHC-2001.pdf
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Marc: |
LEADER 01328nam a2200241 a 4500
001 1008027
005 2020-02-10
008 2001 bl uuuu u00u1 u #d
020 $a85-88442-09-4
100 1 $aROCHA, H. V. da
245 $aDesign de ambientes para EaD$b(re) significações do usuário.$h[electronic resource]
260 $aIn: WORKSHOP SOBRE FATORES HUMANOS EM SISTEMAS COMPUTACIONAIS, 4., 2001, Florianópolis. Anais... Florianópolis: UFSC/SBC$c2001
300 $ap. 84-95.
500 $aIHC 2001.
520 $aEste trabalho descreve e discute alguns dados relacionados ao uso alternativo de algumas ferramentas do ambiente TelEduc para EaD, coletados no decorrer de vários cursos a distância. A análise dos dados indica que os usuários reinterpretam as intenções do designer desenvolvendo um modelo muitas vezes distante do modelo conceitual do design do ambiente. E, de certa forma contraditoriamente aos resultados da área de IHC, esta possibilidade de múltiplas reinterpretações por parte do usuário é desejável, considerando-se a tarefa de educar a distância.
650 $aDistance education
650 $aLearning
653 $aDesign de ambientes
653 $aEducação à distância
653 $aTelEduc
700 1 $aOEIRAS, J. Y. Y.
700 1 $aFREIRE, F. M. P.
700 1 $aROMANI, L. A. S.
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Embrapa Agricultura Digital (CNPTIA) |
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