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Registro Completo |
Biblioteca(s): |
Embrapa Amapá. |
Data corrente: |
22/09/2022 |
Data da última atualização: |
14/12/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
MADRID, R. R. M; MATHEWS, P. D.; PATTA, A. C. F.; GONZALES-FLORES, A. P.; RAMIREZ. C. A. B.; RIGONI, V. L. S.; TAVARES-DIAS, M.; MERTINS, O. |
Afiliação: |
RAFAEL R. M. MADRID, UNIVERSIDADE FEDERAL DE SÃO PAULO; PATRICK D. MATHEWS, UNIVERSIDADE FEDERAL DE SÃO PAULO; ANA C. M. F. PATTA, UNIVERSIDADE FEDERAL DE SÃO PAULO; ANAI P. GONZALES-FLORES, INSTITUTE OF RESEARCH OF THE PERUVIAN AMAZON; CARLOS A. B. RAMIREZ, UNIVERSIDADE FEDERAL DE SÃO PAULO; VERA L. S. RIGONI, UNIVERSIDADE FEDERAL DE SÃO PAULO; MARCOS TAVARES DIAS, CPAF-AP; OMAR MERTINS, UNIVERSIDADE FEDERAL DE SÃO PAULO. |
Título: |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Heliyon, v. 7, n. 1, e05820, Jan. 2021. |
DOI: |
https://doi.org/10.1016/j.heliyon.2020.e05820 |
Idioma: |
Inglês |
Conteúdo: |
The FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anticancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed in vivo tissue responses for high doses of ivermectin using Corydoras fish as animal model. We made intestinal histology and hematologic assays after oral administration of ivermectin transported with polyelectrolytes formulation. Histology showed any apparent damage of intestinal tissues at 0.22?170 mg of ivermectin/kg body weight. Immunofluorescence evidenced delocalization of Myosin-Vb at enterocytes only for the higher dose. Hematology parameters showed random variations after 7 days from administration, but a later apparent recover after 14 and 21 days. The study evaluated the potential of high doses of oral administration of ivermectin formulation, which could be an alternative with benefits in high compliance therapies. |
Thesagro: |
Peixe. |
Thesaurus Nal: |
Corydoras; Ivermectin. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1146721/1/CPAF-AP-2022-Safety-of-oral-administration-of-high-doses-of-ivermectin.pdf
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Marc: |
LEADER 01803naa a2200253 a 4500 001 2146721 005 2022-12-14 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.heliyon.2020.e05820$2DOI 100 1 $aMADRID, R. R. M 245 $aSafety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation.$h[electronic resource] 260 $c2021 520 $aThe FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anticancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed in vivo tissue responses for high doses of ivermectin using Corydoras fish as animal model. We made intestinal histology and hematologic assays after oral administration of ivermectin transported with polyelectrolytes formulation. Histology showed any apparent damage of intestinal tissues at 0.22?170 mg of ivermectin/kg body weight. Immunofluorescence evidenced delocalization of Myosin-Vb at enterocytes only for the higher dose. Hematology parameters showed random variations after 7 days from administration, but a later apparent recover after 14 and 21 days. The study evaluated the potential of high doses of oral administration of ivermectin formulation, which could be an alternative with benefits in high compliance therapies. 650 $aCorydoras 650 $aIvermectin 650 $aPeixe 700 1 $aMATHEWS, P. D. 700 1 $aPATTA, A. C. F. 700 1 $aGONZALES-FLORES, A. P. 700 1 $aRAMIREZ. C. A. B. 700 1 $aRIGONI, V. L. S. 700 1 $aTAVARES-DIAS, M. 700 1 $aMERTINS, O. 773 $tHeliyon$gv. 7, n. 1, e05820, Jan. 2021.
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Embrapa Amapá (CPAF-AP) |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
Data corrente: |
20/10/2006 |
Data da última atualização: |
30/07/2018 |
Autoria: |
NASCIMENTO, L. C. do; PENSUK, V.; COSTA, N. P. da; ASSIS FILHO, F. M. de; PIO-RIBEIRO, G.; DEOM, C. M.; SHERWOOD, J. |
Afiliação: |
Luciana Cordeiro do Nascimento, Universidade Federal da Paraíba - UFPB/Departamento de Fitotecnia; Viboon Pensuk, Udonthani Rajabhat University/Deptament of Technology; Nivânia Pereira da Costa, Universidade Federal da Paraíba - UFPB/Departamento de Fitotecnia; Francisco Miguel de Assis Filho, Agdia Incorporated; Gilvan Pio-Ribeiro, Universidade Federal de Pernambuco -UFPB/Departamento de Agronomia; Carl Michael Deom, University of Georgia/Deptament of Plant Pathology; John Sherwood, University of Georgia/Deptament of Plant Pathology. |
Título: |
Evaluation of peanut genotypes for resistance to Tomato spotted wilt virus by mechanical and thrips inoculation. |
Ano de publicação: |
2006 |
Fonte/Imprenta: |
Pesquisa Agropecuária Brasileira, Brasília, DF, v. 41, n. 6, p. 937-942, jun. 2006 |
Idioma: |
Inglês |
Notas: |
Título em português: Avaliação de genótipos de amendoim em relação à resistência ao Tomato spotted wilt virus por meio de inoculação mecânica e por tripes. |
Conteúdo: |
The objective of this work was to evaluate the reactions of three peanut breeding lines (IC-10, IC-34, and ICGV 86388) to Tomato spotted wilt virus (TSWV) by mechanical and thrips inoculation, under greenhouse conditions, and compare them to the reactions of cultivars SunOleic, Georgia Green, and the breeding line C11-2-39. TSWV infection by mechanical inoculation was visually assessed using an index ranging from 0 (no symptoms) to 4 (apical death). Enzyme-linked immunosorbent assay was used to confirm TSWV infection from both mechanical and thrips inoculations. IC-10, IC-34, ICGV 86388, and C11-2-39 were more resistant than the cultivars SunOleic and Georgia Green based on mechanical inoculation. Upon thrips inoculation only IC-34 and ICGV-86388 were infected by TSWV, as demonstrated by reverse transcription polymerase chain reaction (RT-PCR), although no symptoms of infection were observed. The peanut breeding lines IC-10, IC-34, and ICGV 86388 show higher level of resistance to TSWV than cultivar Georgia Green considered a standard for TSWV resistance. |
Palavras-Chave: |
mechanical transmission; thrips transmission; transmissão mecânica; transmissão por tripes; TSWV. |
Thesagro: |
Arachis Hypogaea. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/107197/1/Evaluation.pdf
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Marc: |
LEADER 02077naa a2200277 a 4500 001 1109114 005 2018-07-30 008 2006 bl uuuu u00u1 u #d 100 1 $aNASCIMENTO, L. C. do 245 $aEvaluation of peanut genotypes for resistance to Tomato spotted wilt virus by mechanical and thrips inoculation. 260 $c2006 500 $aTítulo em português: Avaliação de genótipos de amendoim em relação à resistência ao Tomato spotted wilt virus por meio de inoculação mecânica e por tripes. 520 $aThe objective of this work was to evaluate the reactions of three peanut breeding lines (IC-10, IC-34, and ICGV 86388) to Tomato spotted wilt virus (TSWV) by mechanical and thrips inoculation, under greenhouse conditions, and compare them to the reactions of cultivars SunOleic, Georgia Green, and the breeding line C11-2-39. TSWV infection by mechanical inoculation was visually assessed using an index ranging from 0 (no symptoms) to 4 (apical death). Enzyme-linked immunosorbent assay was used to confirm TSWV infection from both mechanical and thrips inoculations. IC-10, IC-34, ICGV 86388, and C11-2-39 were more resistant than the cultivars SunOleic and Georgia Green based on mechanical inoculation. Upon thrips inoculation only IC-34 and ICGV-86388 were infected by TSWV, as demonstrated by reverse transcription polymerase chain reaction (RT-PCR), although no symptoms of infection were observed. The peanut breeding lines IC-10, IC-34, and ICGV 86388 show higher level of resistance to TSWV than cultivar Georgia Green considered a standard for TSWV resistance. 650 $aArachis Hypogaea 653 $amechanical transmission 653 $athrips transmission 653 $atransmissão mecânica 653 $atransmissão por tripes 653 $aTSWV 700 1 $aPENSUK, V. 700 1 $aCOSTA, N. P. da 700 1 $aASSIS FILHO, F. M. de 700 1 $aPIO-RIBEIRO, G. 700 1 $aDEOM, C. M. 700 1 $aSHERWOOD, J. 773 $tPesquisa Agropecuária Brasileira, Brasília, DF$gv. 41, n. 6, p. 937-942, jun. 2006
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