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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
14/08/2020 |
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Data da última atualização: |
10/09/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LIMA, A. O. de; KOLTES, J. E.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; CESAR, A. S. M.; TIZIOTO, P. L.; AFONSO, J.; SOUZA, M. de S.; PETRINI, J.; ROCHA, M. I. P.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. |
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Afiliação: |
ANDRESSA O. DE LIMA, UFSCar; JAMES E. KOLTES, Iowa State University; WELLISON J. S. DINIZ, UFSCar; PRISCILA S. N. DE OLIVEIRA; ALINE S. M. CESAR, Esalq/USP; POLYANA C. TIZIOTO, NGS Genomic Solution; JULIANA AFONSO, UFSCar; MARCELA M. DE SOUZA, Iowa State University; JULIANA PETRINI, UNIFAL; MARINA I. P. ROCHA, UFSCar; TAINÃ F. CARDOSO; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ L. COUTINHO, Esalq/USP; GERSON B. MOURÃO, Esalq/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Potential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Frontiers in Genetics, v. 11, p. 1-14, Mar. 2020. |
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DOI: |
https://doi.org/10.3389/fgene.2020.00189 |
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Idioma: |
Inglês |
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Notas: |
Article 189. Na publicação: Luciana C. A. Regitano. |
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Conteúdo: |
Feed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors (TFs) ELF1, ELK3, ETS1, FLI1, and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1, and OGN was associated with multiple feed efficiency-related traits (FDR ≤ 0.05) and were previously related to glucose homeostasis, oxidative stress, fat mass, and osteoblastogenesis, respectively. Potential regulatory elements were identified, integrating the hub genes with previous studies from our research group, such as the putative cis-regulatory elements (eQTLs) inferred as affecting the PCDH18 and SPARCL1 hub genes related to immune system and adipogenesis, respectively. Therefore, our analyses contribute to a better understanding of the biological mechanisms underlying feed efficiency in bovine and the hub genes disclosed can be used as biomarkers for feed efficiency-related traits in Nelore cattle. |
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Palavras-Chave: |
Biomarcadores; Expressão gênica; Feed efficiency; Hub genes; Longissimus thoracis; Systems biology; WGCNA. |
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Thesagro: |
Bos Indicus. |
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Thesaurus Nal: |
Gene expression. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/215312/1/AP-Potential-biomarkers-2020.pdf
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Marc: |
LEADER 02711naa a2200421 a 4500
001 2124356
005 2020-09-10
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3389/fgene.2020.00189$2DOI
100 1 $aLIMA, A. O. de
245 $aPotential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses.$h[electronic resource]
260 $c2020
500 $aArticle 189. Na publicação: Luciana C. A. Regitano.
520 $aFeed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors (TFs) ELF1, ELK3, ETS1, FLI1, and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1, and OGN was associated with multiple feed efficiency-related traits (FDR ≤ 0.05) and were previously related to glucose homeostasis, oxidative stress, fat mass, and osteoblastogenesis, respectively. Potential regulatory elements were identified, integrating the hub genes with previous studies from our research group, such as the putative cis-regulatory elements (eQTLs) inferred as affecting the PCDH18 and SPARCL1 hub genes related to immune system and adipogenesis, respectively. Therefore, our analyses contribute to a better understanding of the biological mechanisms underlying feed efficiency in bovine and the hub genes disclosed can be used as biomarkers for feed efficiency-related traits in Nelore cattle.
650 $aGene expression
650 $aBos Indicus
653 $aBiomarcadores
653 $aExpressão gênica
653 $aFeed efficiency
653 $aHub genes
653 $aLongissimus thoracis
653 $aSystems biology
653 $aWGCNA
700 1 $aKOLTES, J. E.
700 1 $aDINIZ, W. J. S.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aCESAR, A. S. M.
700 1 $aTIZIOTO, P. L.
700 1 $aAFONSO, J.
700 1 $aSOUZA, M. de S.
700 1 $aPETRINI, J.
700 1 $aROCHA, M. I. P.
700 1 $aCARDOSO, T. F.
700 1 $aZERLOTINI NETO, A.
700 1 $aCOUTINHO, L. L.
700 1 $aMOURÃO, G. B.
700 1 $aREGITANO, L. C. de A.
773 $tFrontiers in Genetics$gv. 11, p. 1-14, Mar. 2020.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Solos. Para informações adicionais entre em contato com cnps.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Agropecuária Oeste; Embrapa Cerrados; Embrapa Solos. |
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Data corrente: |
29/01/2021 |
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Data da última atualização: |
27/10/2021 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
LANDERS, J. N.; FREITAS, P. L. de; BALBINO, L. C.; SALTON, J. C.; MARCHAO, R. L. |
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Afiliação: |
JOHN N. LANDERS, CONSULTOR INDEPENDENTE; PEDRO LUIZ DE FREITAS, CNPS; LUIZ CARLOS BALBINO, CPAC; JULIO CESAR SALTON, CPAO; ROBELIO LEANDRO MARCHAO, CPAC. |
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Título: |
Integration of crop-livestock in conservation agriculture systems. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
In: KASSAM, A. (ed.). Advances in conservation agriculture. Cambridge: Burleigh Dodds Science Publishing, 2020. v. 1, 68 p. |
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DOI: |
http://dx.doi.org/10.19103/AS.2019.0048.10 |
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Idioma: |
Inglês |
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Conteúdo: |
This chapter draws heavily on Brazilian experience, not only because of author affiliations, but due to the fact that Brazil is a current world leader in ICL-CA and in Integrated Crop-Livestock-Forestry management systems under CA (ICLF-CA) adoption and research, currently with 11.5 million hectares under these systems (83% under ICL-CA ) and a government-sponsored Low Carbon Agriculture programme supporting research and extension towards achieving Brazil's international goals to reduce greenhouse gas (GHG) emissions The process of pasture degradation will not be covered here, since it is dealt with in detail by other authors referred to in the text; it is considerably reduced, or eliminated, by ICL-CA. |
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Palavras-Chave: |
Agricultura Conservacionista. |
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Thesagro: |
Produção Integrada; Sistema de Produção. |
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Thesaurus NAL: |
Integrated agricultural systems. |
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Categoria do assunto: |
P Recursos Naturais, Ciências Ambientais e da Terra |
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Marc: |
LEADER 01508naa a2200229 a 4500
001 2129689
005 2021-10-27
008 2020 bl uuuu u00u1 u #d
024 7 $ahttp://dx.doi.org/10.19103/AS.2019.0048.10$2DOI
100 1 $aLANDERS, J. N.
245 $aIntegration of crop-livestock in conservation agriculture systems.$h[electronic resource]
260 $c2020
520 $aThis chapter draws heavily on Brazilian experience, not only because of author affiliations, but due to the fact that Brazil is a current world leader in ICL-CA and in Integrated Crop-Livestock-Forestry management systems under CA (ICLF-CA) adoption and research, currently with 11.5 million hectares under these systems (83% under ICL-CA ) and a government-sponsored Low Carbon Agriculture programme supporting research and extension towards achieving Brazil's international goals to reduce greenhouse gas (GHG) emissions The process of pasture degradation will not be covered here, since it is dealt with in detail by other authors referred to in the text; it is considerably reduced, or eliminated, by ICL-CA.
650 $aIntegrated agricultural systems
650 $aProdução Integrada
650 $aSistema de Produção
653 $aAgricultura Conservacionista
700 1 $aFREITAS, P. L. de
700 1 $aBALBINO, L. C.
700 1 $aSALTON, J. C.
700 1 $aMARCHAO, R. L.
773 $tIn: KASSAM, A. (ed.). Advances in conservation agriculture. Cambridge: Burleigh Dodds Science Publishing, 2020.$gv. 1, 68 p.
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