02711naa a2200421 a 450000100080000000500110000800800410001902400500006010000190011024501710012926000090030050000580030952014210036765000200178865000160180865300180182465300230184265300200186565300140188565300250189965300200192465300100194470000180195470000200197270000260199270000200201870000190203870000150205770000200207270000160209270000200210870000190212870000230214770000200217070000190219070000260220977300540223521243562020-09-10       2020    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.3389/fgene.2020.001892DOI1 aLIMA, A. O. de  aPotential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses.h[electronic resource]  c2020  aArticle 189. Na publicação: Luciana C. A. Regitano.  aFeed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors (TFs) ELF1, ELK3, ETS1, FLI1, and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1, and OGN was associated with multiple feed efficiency-related traits (FDR ≤ 0.05) and were previously related to glucose homeostasis, oxidative stress, fat mass, and osteoblastogenesis, respectively. Potential regulatory elements were identified, integrating the hub genes with previous studies from our research group, such as the putative cis-regulatory elements (eQTLs) inferred as affecting the PCDH18 and SPARCL1 hub genes related to immune system and adipogenesis, respectively. Therefore, our analyses contribute to a better understanding of the biological mechanisms underlying feed efficiency in bovine and the hub genes disclosed can be used as biomarkers for feed efficiency-related traits in Nelore cattle.  aGene expression  aBos Indicus  aBiomarcadores  aExpressão gênica  aFeed efficiency  aHub genes  aLongissimus thoracis  aSystems biology  aWGCNA1 aKOLTES, J. E.1 aDINIZ, W. J. S.1 aOLIVEIRA, P. S. N. de1 aCESAR, A. S. M.1 aTIZIOTO, P. L.1 aAFONSO, J.1 aSOUZA, M. de S.1 aPETRINI, J.1 aROCHA, M. I. P.1 aCARDOSO, T. F.1 aZERLOTINI NETO, A.1 aCOUTINHO, L. L.1 aMOURÃO, G. B.1 aREGITANO, L. C. de A.  tFrontiers in Geneticsgv. 11, p. 1-14, Mar. 2020.