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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
20/04/2010 |
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Data da última atualização: |
16/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ALVES, C. C. de S.; AZEVEDO, A. L. S.; RODRIGUES, M. F.; MACHADO, R. P.; SOUZA, M. A.; MACHADO, M. A.; TEIXEIRA, H. C.; FERREIRA, A. P. |
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Afiliação: |
CAIO CÉSAR DE SOUZA ALVES, UFJF; ANA LUISA SOUSA AZEVEDO, CNPGL; MICHELE F. RODRIGUES, UFJF; RACHEL P. MACHADO, UFJF; SUPREMA; MARIA A. SOUZA, UFJF; MARCO ANTONIO MACHADO, CNPGL; HENRIQUE C. TEIXEIRA, UFJF; ANA P. FERREIRA, UFJF. |
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Título: |
Cellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice. |
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Ano de publicação: |
2009 |
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Fonte/Imprenta: |
Comparative Immunology, Microbiology and Infectious Discases, v. 32, n. 6, p. 513-525, 2009. |
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DOI: |
https://doi.org/10.1016/j.cimid.2008.07.006 |
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Idioma: |
Inglês |
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Conteúdo: |
Paracoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-γ production was highest on day 15 p.i., declining thereafter. The kinetics of the NO production was similar to that described for IFN-γ. In contrast, IL-10 increased from day 45 p.i. reaching a peak at day 90. Levels of serum IgG1 were higher than IgG2a between days 30 and 90 p.i. 30% of mice died by day 90 p.i. These data indicate that infection with P. brasiliensis by the intrathoracic route shows high IFN-γ and NO production at day 15 p.i., unable to control multiplication of fungi, which appears to be associated with a progressive increase in IL-10 and in the number and complexity of granulomas. |
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Palavras-Chave: |
Antibody response; IFN-y; IL-10; Intrathoracic route. |
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Thesaurus Nal: |
Paracoccidioides brasiliensis. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/697051/1/Cellular-and-humoral-immune-responses-during-intrathoracic-paracoccidioidomycosis.pdf
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Marc: |
LEADER 01861naa a2200277 a 4500
001 1697051
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024 7 $ahttps://doi.org/10.1016/j.cimid.2008.07.006$2DOI
100 1 $aALVES, C. C. de S.
245 $aCellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice.$h[electronic resource]
260 $c2009
520 $aParacoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-γ production was highest on day 15 p.i., declining thereafter. The kinetics of the NO production was similar to that described for IFN-γ. In contrast, IL-10 increased from day 45 p.i. reaching a peak at day 90. Levels of serum IgG1 were higher than IgG2a between days 30 and 90 p.i. 30% of mice died by day 90 p.i. These data indicate that infection with P. brasiliensis by the intrathoracic route shows high IFN-γ and NO production at day 15 p.i., unable to control multiplication of fungi, which appears to be associated with a progressive increase in IL-10 and in the number and complexity of granulomas.
650 $aParacoccidioides brasiliensis
653 $aAntibody response
653 $aIFN-y
653 $aIL-10
653 $aIntrathoracic route
700 1 $aAZEVEDO, A. L. S.
700 1 $aRODRIGUES, M. F.
700 1 $aMACHADO, R. P.
700 1 $aSOUZA, M. A.
700 1 $aMACHADO, M. A.
700 1 $aTEIXEIRA, H. C.
700 1 $aFERREIRA, A. P.
773 $tComparative Immunology, Microbiology and Infectious Discases$gv. 32, n. 6, p. 513-525, 2009.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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