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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
14/08/2020 |
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Data da última atualização: |
10/09/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LIMA, A. O. de; KOLTES, J. E.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; CESAR, A. S. M.; TIZIOTO, P. L.; AFONSO, J.; SOUZA, M. de S.; PETRINI, J.; ROCHA, M. I. P.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. |
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Afiliação: |
ANDRESSA O. DE LIMA, UFSCar; JAMES E. KOLTES, Iowa State University; WELLISON J. S. DINIZ, UFSCar; PRISCILA S. N. DE OLIVEIRA; ALINE S. M. CESAR, Esalq/USP; POLYANA C. TIZIOTO, NGS Genomic Solution; JULIANA AFONSO, UFSCar; MARCELA M. DE SOUZA, Iowa State University; JULIANA PETRINI, UNIFAL; MARINA I. P. ROCHA, UFSCar; TAINÃ F. CARDOSO; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ L. COUTINHO, Esalq/USP; GERSON B. MOURÃO, Esalq/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Potential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Frontiers in Genetics, v. 11, p. 1-14, Mar. 2020. |
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DOI: |
https://doi.org/10.3389/fgene.2020.00189 |
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Idioma: |
Inglês |
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Notas: |
Article 189. Na publicação: Luciana C. A. Regitano. |
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Conteúdo: |
Feed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors (TFs) ELF1, ELK3, ETS1, FLI1, and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1, and OGN was associated with multiple feed efficiency-related traits (FDR ≤ 0.05) and were previously related to glucose homeostasis, oxidative stress, fat mass, and osteoblastogenesis, respectively. Potential regulatory elements were identified, integrating the hub genes with previous studies from our research group, such as the putative cis-regulatory elements (eQTLs) inferred as affecting the PCDH18 and SPARCL1 hub genes related to immune system and adipogenesis, respectively. Therefore, our analyses contribute to a better understanding of the biological mechanisms underlying feed efficiency in bovine and the hub genes disclosed can be used as biomarkers for feed efficiency-related traits in Nelore cattle. |
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Palavras-Chave: |
Biomarcadores; Expressão gênica; Feed efficiency; Hub genes; Longissimus thoracis; Systems biology; WGCNA. |
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Thesagro: |
Bos Indicus. |
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Thesaurus Nal: |
Gene expression. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/215312/1/AP-Potential-biomarkers-2020.pdf
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Marc: |
LEADER 02711naa a2200421 a 4500
001 2124356
005 2020-09-10
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3389/fgene.2020.00189$2DOI
100 1 $aLIMA, A. O. de
245 $aPotential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses.$h[electronic resource]
260 $c2020
500 $aArticle 189. Na publicação: Luciana C. A. Regitano.
520 $aFeed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors (TFs) ELF1, ELK3, ETS1, FLI1, and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1, and OGN was associated with multiple feed efficiency-related traits (FDR ≤ 0.05) and were previously related to glucose homeostasis, oxidative stress, fat mass, and osteoblastogenesis, respectively. Potential regulatory elements were identified, integrating the hub genes with previous studies from our research group, such as the putative cis-regulatory elements (eQTLs) inferred as affecting the PCDH18 and SPARCL1 hub genes related to immune system and adipogenesis, respectively. Therefore, our analyses contribute to a better understanding of the biological mechanisms underlying feed efficiency in bovine and the hub genes disclosed can be used as biomarkers for feed efficiency-related traits in Nelore cattle.
650 $aGene expression
650 $aBos Indicus
653 $aBiomarcadores
653 $aExpressão gênica
653 $aFeed efficiency
653 $aHub genes
653 $aLongissimus thoracis
653 $aSystems biology
653 $aWGCNA
700 1 $aKOLTES, J. E.
700 1 $aDINIZ, W. J. S.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aCESAR, A. S. M.
700 1 $aTIZIOTO, P. L.
700 1 $aAFONSO, J.
700 1 $aSOUZA, M. de S.
700 1 $aPETRINI, J.
700 1 $aROCHA, M. I. P.
700 1 $aCARDOSO, T. F.
700 1 $aZERLOTINI NETO, A.
700 1 $aCOUTINHO, L. L.
700 1 $aMOURÃO, G. B.
700 1 $aREGITANO, L. C. de A.
773 $tFrontiers in Genetics$gv. 11, p. 1-14, Mar. 2020.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pantanal. Para informações adicionais entre em contato com cpap.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
27/11/2017 |
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Data da última atualização: |
27/11/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 4 |
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Autoria: |
FERNANDES, G. W.; VALE, M. M.; OVERBECK, G. E.; BUSTAMANTE, M. M. C.; GRELLE, C. E. V.; BERGALLO, H. G.; MAGNUSSON, W. E.; AKAMA, A.; ALVES, S.; AMORIM, A.; ARAÚJO, J.; BARROS, C. F.; BRAVO, F.; CARIM, M. J. V.; CERQUEIRA, R.; COLLEVATTI, R. G.; COLLI, G. R.; CUNHA, C. N. da; D’ANDREA, P. S.; DIANESE, J. C.; DINIZ, S.; ESTRELA, P. C.; FERNANDES, M. R. M.; FONTANA, C. S.; GIACOMIN, L. L.; GUSMÃO, L. F. P.; JUNCÁ, F. A.; LINS-E-SILVA, A. C. B.; LOPES, C. R. A. S.; LORINI, M. L.; QUEIROZ, L. P. de; MALABARBA, L. R.; MARIMON, B. S.; MARIMON JUNIOR, B. H.; MARQUES, M. C. M.; MARTINELLI, B. M.; MARTINS, M. B.; MEDEIROS, H. F. de; MENIN, M.; MORAIS, P. B. de; MUNIZ, F. H.; NECKEL-OLIVEIRA, S.; OLIVEIRA, J. A. de; OLIVEIRA, R. P.; PEDRONI, F.; PENHA, J.; PODGAISKI, L. R.; RODRIGUES, D. J.; SCARIOT, A.; SILVEIRA, L. F.; SILVEIRA, M.; TOMAS, W. M.; VITAL, M. J. S.; PILLAR, V. D. |
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Afiliação: |
G. WILSON FERNANDES, UFMG; MARIANA M. VALE, UFRJ; GERHARD E. OVERBECK, UFRGS; MERCEDES M. C. BUSTAMANTE, UNB; CARLOS E. V. GRELLE, UFRJ; HELENA GODOY BERGALLO, UERJ; WILLIAM E. MAGNUSSON, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; ALBERTO AKAMA, MUSEU PARAENSE EMÍLIO GOELDI; SUELEN S. ALVES, UFSM; ANDRÉ AMORIM, UESC; JOAQUIM ARAÚJO, INSTITUTO BIOTRÓPICOS; CLAUDIA FRANCA BARROS, INSTITUTO DE PESQUISAS JARDIM BOTÂNICO DO RIO DE JANEIRO; FREDDY BRAVO, UEFS; MARCELO J. VEIGA CARIM, NÚCLEO DO PPBIO AMAPÁ; RUI CERQUEIRA, UFRJ; ROSANE GARCIA COLLEVATTI, UFG; GUARINO R. COLLI, UNB; CATIA NUNES DA CUNHA, UFMT; PAULO SERGIO D’ANDREA, INSTITUTO OSWALDO CRUZ/FIOCRUZ; JOSÉ CARMINE DIANESE, UNB; SORAIA DINIZ, UFMT; PEDRO CORDEIRO ESTRELA, UFPB; MARILUCE R. M. FERNANDES, UNIR; CARLA SUERTEGARAY FONTANA, PUCRS, MUSEU DE CIÊNCIAS E TECNOLOGIA; LEANDRO L. GIACOMIN, UFOPA; LUIS FERNANDO P. GUSMÃO, UEFS; FLORA ACUÑA JUNCÁ, UEFS; ANA CAROLINA BORGES LINS-E-SILVA, UFRPE; CELIA R. A. S. LOPES, UNEMAT; MARIA LUCIA LORINI, UNIRIO; LUCIANO PAGANUCCI DE QUEIROZ, UEFS; LUIZ R. MALABARBA, UFRGS; BEATRIZ SCHWANTES MARIMON, UNEMAT; BEN HUR MARIMON JUNIOR, UNEMAT; MARCIA C. M. MARQUES, UFPR; BRUNO M. MARTINELLI, UNB; MARLUCIA BONIFACIO MARTINS, MUSEU PARAENSE EMÍLIO GOELDI; HERMES FONSECA DE MEDEIROS, UFPA; MARCELO MENIN, UFAM; PAULA BENEVIDES DE MORAIS, UFT; FRANCISCA HELENA MUNIZ, UEMA; SELVINO NECKEL-OLIVEIRA, UFSC; JOÃO ALVES DE OLIVEIRA, MUSEU NACIONAL DO RIO DE JANEIRO; REYJANE P. OLIVEIRA, UEFS; FERNANDO PEDRONI, UFMT; JERRY PENHA, UFMT; LUCIANA R. PODGAISKI, UFRGS; DOMINGOS J. RODRIGUES, UFMT; ALDICIR OSNI SCARIOT, Cenargen; LUÍS FÁBIO SILVEIRA, USP; MARCOS SILVEIRA, UFAC; WALFRIDO MORAES TOMAS, CPAP; MARCOS J. SALGADO VITAL, UFRR; VALÉRIO D. PILLAR, UFRGS. |
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Título: |
Dismantling Brazil's science threatens global biodiversity heritage. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Perspectives in Ecology and Conservation, v. 15, p. 239-243, 2017. |
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DOI: |
10.1016/j.pecon.2017.07.004 |
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Idioma: |
Inglês |
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Conteúdo: |
In the middle of a political and fiscal crisis, the Brazilian government is applying successive budget cuts,including in science funding. Recent cuts radically affect research programs on biodiversity that arecrucial components for the design and monitoring of public policies for nature conservation and sustain-able development. We analyze the consequences of such cuts on the Research Program on Biodiversity(PPBio), the largest biodiversity research network in Brazil (626 researchers, nine networks in all Brazil-ian biomes). Brazil holds a substantial part of the world's biodiversity and of tropical forests that play asignificant role for regional and global climate stability. If underfunding is maintained, the dismantlingof the Brazilian PPBio will have consequences that go beyond biodiversity knowledge itself but affectsociety as a whole. Brazil will likely fail to reach the National Targets for Biodiversity 2011-2020, and itwill be difficult to fulfill the restoration target of the Brazilian NDC and to advance with the sustainabledevelopment goals. |
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Palavras-Chave: |
Biodiversity research network; Global environmental commitments; Research Program on Biodiversity(PPBio). |
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Thesagro: |
Depressão Econômica; Programa de Pesquisa. |
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Thesaurus NAL: |
Economic incentives; Research programs. |
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Categoria do assunto: |
D Governo, Leis e Regulamentações |
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Marc: |
LEADER 03438naa a2200853 a 4500
001 2080731
005 2017-11-27
008 2017 bl --- 0-- u #d
024 7 $a10.1016/j.pecon.2017.07.004$2DOI
100 1 $aFERNANDES, G. W.
245 $aDismantling Brazil's science threatens global biodiversity heritage.
260 $c2017
520 $aIn the middle of a political and fiscal crisis, the Brazilian government is applying successive budget cuts,including in science funding. Recent cuts radically affect research programs on biodiversity that arecrucial components for the design and monitoring of public policies for nature conservation and sustain-able development. We analyze the consequences of such cuts on the Research Program on Biodiversity(PPBio), the largest biodiversity research network in Brazil (626 researchers, nine networks in all Brazil-ian biomes). Brazil holds a substantial part of the world's biodiversity and of tropical forests that play asignificant role for regional and global climate stability. If underfunding is maintained, the dismantlingof the Brazilian PPBio will have consequences that go beyond biodiversity knowledge itself but affectsociety as a whole. Brazil will likely fail to reach the National Targets for Biodiversity 2011-2020, and itwill be difficult to fulfill the restoration target of the Brazilian NDC and to advance with the sustainabledevelopment goals.
650 $aEconomic incentives
650 $aResearch programs
650 $aDepressão Econômica
650 $aPrograma de Pesquisa
653 $aBiodiversity research network
653 $aGlobal environmental commitments
653 $aResearch Program on Biodiversity(PPBio)
700 1 $aVALE, M. M.
700 1 $aOVERBECK, G. E.
700 1 $aBUSTAMANTE, M. M. C.
700 1 $aGRELLE, C. E. V.
700 1 $aBERGALLO, H. G.
700 1 $aMAGNUSSON, W. E.
700 1 $aAKAMA, A.
700 1 $aALVES, S.
700 1 $aAMORIM, A.
700 1 $aARAÚJO, J.
700 1 $aBARROS, C. F.
700 1 $aBRAVO, F.
700 1 $aCARIM, M. J. V.
700 1 $aCERQUEIRA, R.
700 1 $aCOLLEVATTI, R. G.
700 1 $aCOLLI, G. R.
700 1 $aCUNHA, C. N. da
700 1 $aD’ANDREA, P. S.
700 1 $aDIANESE, J. C.
700 1 $aDINIZ, S.
700 1 $aESTRELA, P. C.
700 1 $aFERNANDES, M. R. M.
700 1 $aFONTANA, C. S.
700 1 $aGIACOMIN, L. L.
700 1 $aGUSMÃO, L. F. P.
700 1 $aJUNCÁ, F. A.
700 1 $aLINS-E-SILVA, A. C. B.
700 1 $aLOPES, C. R. A. S.
700 1 $aLORINI, M. L.
700 1 $aQUEIROZ, L. P. de
700 1 $aMALABARBA, L. R.
700 1 $aMARIMON, B. S.
700 1 $aMARIMON JUNIOR, B. H.
700 1 $aMARQUES, M. C. M.
700 1 $aMARTINELLI, B. M.
700 1 $aMARTINS, M. B.
700 1 $aMEDEIROS, H. F. de
700 1 $aMENIN, M.
700 1 $aMORAIS, P. B. de
700 1 $aMUNIZ, F. H.
700 1 $aNECKEL-OLIVEIRA, S.
700 1 $aOLIVEIRA, J. A. de
700 1 $aOLIVEIRA, R. P.
700 1 $aPEDRONI, F.
700 1 $aPENHA, J.
700 1 $aPODGAISKI, L. R.
700 1 $aRODRIGUES, D. J.
700 1 $aSCARIOT, A.
700 1 $aSILVEIRA, L. F.
700 1 $aSILVEIRA, M.
700 1 $aTOMAS, W. M.
700 1 $aVITAL, M. J. S.
700 1 $aPILLAR, V. D.
773 $tPerspectives in Ecology and Conservation$gv. 15, p. 239-243, 2017.
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