02106naa a2200277 a 450000100080000000500110000800800410001910000150006024500920007526000090016750001340017652011700031065000230148065000170150365000260152065300190154665300250156565300170159065300200160765300270162770000210165470000220167570000170169770000240171477300900173819610752017-06-13       2013    bl uuuu     u00u1 u    #d1 aSAKABE, R.  aKinetics of chronic inflammation in Nile tilapia fed n-3 and n-6 essential fatty acids.  c2013  aTítulo em português: Cinética da inflamação crônica em tilápia?do?nilo alimentada com ácidos graxos essenciais n?3 e n?6.  aThe objective of this work was to investigate the effect of dietary supplementation with essential fatty acids on the kinetics of macrophage accumulation and giant cell formation in Nile tilapia (Oreochromis niloticus). The supplementation sources were soybean oil (SO, source of omega 6, n‑6) and linseed oil (LO, source of omega 3, n‑3), in the following proportions: 100% SO; 75% SO + 25% LO; 50% SO + 50% LO; 25% SO + 75% LO; and 100% LO (four replicates per treatment). After a feeding period of three months, growth erformance was evaluated, and glass coverslips were implanted into the subcutaneous connective tissue of fish, being removed for examination at 2, 4, 6, and 8 days after implantation. Growth performance did not differ between treatments. Fish fed 100% linseed oil diet had the greatest macrophage accumulation and the fastest Langhans cell formation on the sixth day. On the eighth day, Langhans cells were predominant on the coverslips implanted in the fish feed 75 and 100% linseed oil. n‑3 fatty acids may contribute to macrophage recruitment and giant cell formation in fish chronic inflammatory response to foreign body.  aGrowth performance  aInflammation  aOreochromis Niloticus  aCorpo estranho  aDesempenho produtivo  aForeign body  aLipid nutrition  aResposta inflamatória1 aMORAES, F. R. de1 aBELO, M. A. de A.1 aPILARSKI, F.1 aMORAES, J. R. E. de  tPesquisa Agropecuária Brasileira, Brasília, DFgv. 48, n. 3, p. 313-319, mar. 2013.