02007naa a2200313 a 450000100080000000500110000800800410001910000220006024500860008226000090016850001150017752010010029265000180129365000170131165000280132865000170135665000150137365300230138865300340141165300200144565300190146565300190148470000240150370000180152770000190154570000160156470000210158077300920160119609152017-08-22       2012    bl uuuu     u00u1 u    #d1 aBELO, M. A. de A.  aVitamin C and endogenous cortisol in foreign-body inflammatory response in pacus.  c2012  aTítulo em português: Vitamina C e cortisol endógeno em resposta inflamatória tipo corpo estranho em pacus.  aThe objective of this work was to evaluate the effect of food supplementation with vitamin C on macrophage and multinucleated giant cell (MGC) activities of pacus at two stocking densities. The experiment was carried out in a 2x2x3 split-plot factorial arrangement with: 0 and 500 mg kg?1 vitamin C; 5 and 20 kg m?3 stocking densities; and evaluation times at 3, 6, and 12 days after the subcutaneous implantation of glass coverslips (DPI). The number of macrophages and MGC, as well as cortisol and glucose plasma levels were determined. The number of macrophages and MGC with two to five nuclei was significantly greater in fish supplemented with vitamin C at 5 kg m?3 stocking density at 3 DPI in comparison to nonsupplemented ones. The macrophage and MGC counts were lower in fish with high?plasma cortisol concentration. Supplementation with 500 mg vitamin C benefits macrophage activity on foreign?body inflammation, and high?cortisol concentration has suppressive effects on this response.  aAscorbic acid  aInflammation  aPiaractus mesopotamicus  aInflamação  aVitamina C  aCélula de Langhan  aCélula gigante multinucleada  aGlicocorticoide  aGlucocorticoid  aLanghans cells1 aMORAES, J. R. E. de1 aSOARES, V. E.1 aMARTINS, M. L.1 aBRUM, C. D.1 aMORAES, F. R. de  tPesquisa Agropecuária Brasileira, Brasília, DFgv. 47, n. 7, p. 1015-1021, jul. 2012.