02365nam a2200301 a 450000100080000000500110000800800410001902000180006002400350007810000170011324500520013026000270018230000130020952015970022265000170181965000130183665000170184965300160186665300240188265300200190665300130192665300240193965300250196365300250198865300230201365300130203670000140204919472462013-02-01       2009    bl uuuu     u0uu1 u    #d  a97803878483587 a10.1007/978-0-387-84835-82DOI1 aCOSTELLO, L.  aMitochondria and Cancer.h[electronic resource]  aSpringer eBooks.c2009  cdigital.  aWarburg and the Warburg hypothesis -- The marriage of genomics, proteomics and intermediary metabolism: exciting and dangerous -- Oxidative phosphorylation: the link between metabolism and cancer -- Control of glycosis and oxidative phosphorylation in fast growing tumor cells -- The role of citrate metabolism in prostate malignancy and other tumors -- The role of mitochondria in the lipogenic -- Mitochondrial apoptosis pathways in cancer -- Mitochondrial tumor suppressors and neoplastic transformation -- Mitochondrial DNA mutations and tumorigenesis -- SDHD in parganglioma -- Mitochondria in hematogic maliagncies -- Mitochondria and oncocytomas -- Extracellular matrix signaling by mitochondria -- Mitochondria as biomarkers of cancer -- Mitochondria as target of cancer therapy.&ltP&gtNearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, &ltEM&gtMitochondria and Cancer&lt/EM&gt, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.&lt/P&gt  acell biology  amedicine  amicrobiology  aBiomedicine  aBiomedicine general  aCancer Research  aCytology  aLaboratory Medicine  aMedical laboratories  aMedical Microbiology  aMolecular Medicine  aOncology1 aSINGH, K.