02199naa a2200241 a 450000100080000000500110000800800410001902400500006010000230011024501050013326000090023852014850024765000200173265300110175265300270176365300230179065300090181370000230182270000220184570000180186770000200188577300520190519433072024-02-09       2012    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.3389/fgene.2011.001122DOI1 aSILVA, M. V. G. B.  aBox-cox transformation and random regression models for fecal egg count data.h[electronic resource]  c2012  aAccurate genetic evaluation of livestock is based on appropriate modeling of phenotypic measurements. In ruminants, fecal egg count (FEC) is commonly used to measure resistance to nematodes. FEC values are not normally distributed and logarithmic transformations have been used in an effort to achieve normality before analysis. However, the transformed data are often still not normally distributed, especially when data are extremely skewed. A series of repeated FEC measurements may provide information about the population dynamics of a group or individual. A total of 6375 FEC measures were obtained for 410 animals between 1992 and 2003 from the Beltsville Agricultural Research Center Angus herd. Original data were transformed using an extension of the Box-Cox transformation to approach normality and to estimate (co)variance components. We also proposed using random regression models (RRM) for genetic and non-genetic studies of FEC. Phenotypes were analyzed using RRM and restricted maximum likelihood. Within the different orders of Legendre polynomials used, those with more parameters (order 4) adjusted FEC data best. Results indicated that the transformation of FEC data utilizing the Box-Cox transformation family was effective in reducing the skewness and kurtosis, and dramatically increased estimates of heritability, and measurements of FEC obtained in the period between 12 and 26 weeks in a 26-week experimental challenge period are genetically correlated.  afecal egg count  aBovine  aBox-cox transformation  aGenetic parameters  aREML1 aVAN TASSELL, C. P.1 aSONSTEGARD, T. S.1 aCOBUCI, J. A.1 aGASBARRE, L. C.  tFrontiers in Geneticsgv. 2, article 112, 2012.