01670naa a2200241 a 450000100080000000500110000800800410001910000200006024500940008026000090017452009770018365000100116065000240117070000150119470000170120970000170122670000200124370000190126370000220128270000210130470000230132577300800134819020832017-11-28       2011    bl uuuu     u00u1 u    #d1 aPAMPLONA, J. H.  aSubchronic effects of dipyrone on the fish species Rhamdia quelen.h[electronic resource]  c2011  aThe use of the non-steroidal anti-inflammatory drugs such as dipyrone is so widespread that this drug and its metabolites have been detected in effluents and surface water. This study aimed to evaluate the potential toxic effects of dipyrone on the aquatic environment, using a native fish species, Rhamdia quelen. Fish were exposed to three concentrations of dipyrone, 0.5, 5 and 50 mg/L, in the water for 15 days, and hematological, biochemical, genetic and morphological biomarkers were evaluated. The glutathione S-transferase activity decreased in the highest concentration in relation to the control group. In addition, hematocrit, red blood cells and thrombocyte counts were decreased in all three exposed groups in relation to the control group. The comet assay showed DNA damage at the lowest concentration of dipyrone and significant kidney damage. Those results suggest that a constant exposure of aquatic organisms to dipyrone presents potential toxic effects.  aBagre  aPeixe de água doce1 aOBA, E. T.1 aSILVA, T. A.1 aRAMOS, L. P.1 aRAMSDORF, W. A.1 aCESTARI, M. M.1 aRIBEIRO, C. A. O.1 aZAMPRONIO, A. R.1 aASSIS, H. C. S. de  tEcotoxicology and Environmental Safetygv. 74, n. 3, p. 342-349, Mar. 2011.