02129naa a2200277 a 450000100080000000500110000800800410001910000210006024501570008126000090023852012480024765000160149565000090151165000430152065000220156365000160158565000180160165000190161965000100163865000220164865300250167070000230169570000220171870000200174077300910176019017962022-04-21       2011    bl uuuu     u00u1 u    #d1 aHASHIMOTO, J. C.  aConsiderations on the use of malachite green in aquaculture and analytical aspects of determining the residues in Fishba review.h[electronic resource]  c2011  aAbstract: Aquaculture in Brazil has shown expressive development since the 1990s with growth rates superior to those of cattle and poultry. In order to achieve greater productivity, intensive fish cultivation systems are employed, which can cause greater susceptibility to diseases caused by viruses, bacteria, fungi, and parasites. The reduced availability ofveterinary medications approvedfor use in aquaculture in Brazil has leadfishfarmers to the indiscriminate use of several chemical substances with antimicrobial activity, such as the dye malachite green (MG). As a result of this use, residues of MG and its main biotransformation product, leucomalachite green (LMG), may be present infish available for consumption. The presence of residues of these compounds represents a risk to human health due to their toxicity, as well as a potential impact on the environmenl, and could also raise barriers for commercialiration. in lhe country and for exportation. The objective of this review is to provide the context and evidence of lhe use of MG in aquaculture and of its toxicological and legislative aspects. A review of the analytical methods used to determine MG residues in fish, with emphasis on mass spectrometry, is also presented.  aAquaculture  afish  aHigh performance liquid chromatography  aMass spectrometry  aAquicultura  aCromatografia  aEspectrometria  aPeixe  aResíduo químico  aMalachite green (MO)1 aPASCHOAL, J. A. R.1 aQUEIROZ, J. F. de1 aREYES, F. G. R.  tJournal of Aquatic Food Product Technology, Binghamtongv. 20, n. 3, p. 273-294, 2011.