01320nam a2200229 a 450000100080000000500110000800800410001910000180006024501220007826002450020030000190044550000170046452004370048165000190091865000170093765300210095465300220097565300210099765300430101870000150106170000140107618751002020-01-15       2010    bl uuuu     u00u1 u    #d1 aCASTRO, A. de  aA dynamical approach to study the immunocompetence and the immunological tolerance of mammals.h[electronic resource]  aIn: ANNUAL MEETING OF THE SOCIETY FOR MATHEMATICAL BIOLOGY; INTERNATIONAL SYMPOSIUM ON MATHEMATICAL AND COMPUTATIONAL BIOLOGY, 10., 2010, Rio de Janeiro. Abstracts... Rio de Janeiro: BIOMAT Institute for Advanced Studies of Biosystemsc2010  aNão paginado.  aBIOMAT 2010.  aIn this paper we present an in silico study about immune tolerance, where phase transitions have been observed when antigen dosages were varied in virtual samples. Using a dynamical model to study the behavior of the immune system - presented in a previous edition of the International Symposium on Mathematical and Computational Biology -, we have identified changes in the clonal memory capacity for minimum antigen concentration.  aDynamic models  aImmunoassays  aEstudo in silico  aImunocompetência  aModelo dinâmico  aTolerância imunológica de mamíferos1 aTERNES, S.1 aALVES, D.