01635naa a2200337 a 450000100080000000500110000800800410001902400380006010000180009824501210011626000090023750001160024652005700036265000110093265000170094365000160096065300150097665300210099165300280101265300180104065300260105865300140108465300210109865300260111965300200114565300190116570000180118470000210120270000140122377300600123710827512020-01-15       2009    bl uuuu     u00u1 u    #d7 a10.1007/978-3-642-03223-3_122DOI1 aCASTRO, A. de  aInfluence of antigenic mutations in time evolution of the immune memory - a dynamic modeling.h[electronic resource]  c2009  aProceedings of the 4th Brazilian Symposium on Bioinformatics, 2009, held in Porto Alegre, Brazil, in July 2009.  aIn this paper, we study the behavior of immune memory against antigenic mutation. Using a dynamic model proposed in previous studies, we have performed simulations of several inoculations, where in each virtual sample the viral population undergoes mutations. Our results suggest that the sustainability of the immunizations is dependent on viral variability and that the memory lifetimes are not random, what contradicts what was suggested by recent works. We show that what may cause an apparent random behavior of the immune memoory is the antigenic variability.  aModels  aImunização  aSimulação  aAnticorpos  aB-cell evolution  aEvolução de célula-B  aImmune memory  aMemória imunológica  aModelagem  aModelo dinâmico  aMutação antigênica  aMutação viral  aViral mutation1 aFRONZA, C. F.1 aGIACHETTO, P. F.1 aALVES, D.  tLecture Notes in Computer Sciencegv. 5676, p. 133-142.