01347naa a2200265 a 450000100080000000500110000800800410001910000180006024500850007826000090016352006600017265000110083265000150084365000090085865000110086765300130087865300130089170000150090470000180091970000170093770000160095470000160097070000180098677300770100417997882017-03-31       1999    bl ---       0--  u    #d1 aLIFSCHITZ, A.  aMoxidectin in cattlebcorrelation between plasma and target tissues disposition.  c1999  aThe time of parasite exposure to active drug concentrations determines the persistence of the antiparasitic activity of endectocide compounds. This study evaluates the disposition kinetics of moxidectin (MXD) in plasma and in different target tissues folloeing its subcutaneous (s.c.) administration to cattle. Eighteen male, 10-month old Holstein calves weighing 120-140 kg were subcutaneously injected in the shoulder area with a commercially available formulation of MXD (Cydectin 1%, American Cyanamid, Wayne, NJ, USA) at 200 ug/kg. Two treated calves were killed at each of the following times post-treatment: 1, 4, 8, 18, 28, 38, 48, 58 and 68 days.  acattle  amoxidectin  aGado  aPlasma  aParasita  aParasite1 aVIRKEL, G.1 aIMPERIALE, F.1 aSUTRA, J. F.1 aGALTIER, P.1 aLANUSSE, C.1 aALVINERIE, M.  tJournal Veterinary Pharmacology and Therapeuticsgv.22, p.266-273, 1999.