03234naa a2200601 a 450000100080000000500110000800800410001902400380006010000260009824501120012426000090023652015500024565000180179565000110181365000170182465000210184165000170186265000190187965000220189865000100192065000210193065000190195165000200197065000160199065000250200665000180203165000100204965000210205965000310208065300110211165300110212265300240213365300090215765300300216665300300219665300230222665300200224965300220226965300210229165300220231265300200233470000240235470000200237870000210239870000180241970000240243770000350246170000180249670000160251470000210253070000220255177300590257316578382023-12-05       2009    bl uuuu     u00u1 u    #d7 a10.1016/j.vetpar.2008.10.0182DOI1 aOLIVEIRA, L. M. B. de  aAnthelmintic activity of Cocos nucifera L. against sheep gastrointestinal nematodes.h[electronic resource]  c2009  aThe development of anthelmintic resistance has made the search for alternatives to control gastrointestinal nematodes of small ruminants imperative. Among these alternatives are several medicinal plants traditionally used as anthelmintics. This work evaluated the efficacy of Cocos nucifera fruit on sheep gastrointestinal parasites. The ethyl acetate extract obtained from the liquid of green coconut husk fiber (LGCHF) was submitted to in vitro and in vivo tests. The in vitro assay was based on egg hatching (EHT) and larval development tests (LDT) with Haemonchus contortus. The concentrations tested in the EHT were 0.31, 0.62, 1.25, 2.5 and 5 mg ml1, while in the LDT they were 5, 10, 20, 40 and 80 mg ml1. The in vivo assay was a controlled test. In this experiment, 18 sheep infected with gastrointestinal nematodes were divided into three groups (n = 6), with the following doses administered: G1?400 mg kg1 LGCHF ethyl acetate extract, G2?0.2 mg kg1 moxidectin (Cydectin1) and G3?3% DMSO. The worm burden was analyzed. The results of the in vitro and in vivo tests were submitted to ANOVA and analyzed by the Tukey and Kruskal?Wallis tests, respectively. The extract efficacy in the EHT and LDT, at the highest concentrations tested, was 100% on egg hatching and 99.77% on larval development. The parameters evaluated in the controlled test were not statistically different, showing that despite the significant results of the in vitro tests, the LGCHF ethyl acetate extract showed no activity against sheep gastrointestinal nematodes.  aAnthelmintics  aBrazil  aDrug therapy  aIn vitro studies  aParasitology  aPlant extracts  aProanthocyanidins  aSheep  aAnti-helmíntico  aCocos Nucifera  aExtrato vegetal  aFitoterapia  aHaemonchus Contortus  aLeite de coco  aOvino  aPlanta medicinal  aTratamento fitossanitário  aBrasil  aCeará  aIntestinal diseases  aLCCV  aLíquido da casca de coco  aNematoide gastrintestinal  aParasite Egg Count  aParasito animal  aPequeno ruminante  aProantocianidina  aTanino condensado  aTherapeutic use1 aBEVILAQUA, C. M. L.1 aCOSTA, C. T. C.1 aMACEDO, I. T. F.1 aBARROS, R. S.1 aRODRIGUES, A. C. M.1 aCAMURÇA-VASCONCELOS, A. L. F.1 aMORAIS, S. M.1 aLIMA, Y. C.1 aVIEIRA, L. da S.1 aNAVARRO, A. M. C.  tVeterinary Parasitologygv. 159, n. 1, p. 55-59, 2009.