01335naa a2200253 a 450000100080000000500110000800800410001902400510006010000220011124501550013326000090028852005320029765000190082965000210084865000170086965300210088670000220090770000180092970000230094770000200097070000180099070000150100877300580102315962752025-04-07       2008    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1007/s00249-008-0359-z2DOI1 aMACHADO, R. R. P.  aMetabolic activity interferometerbdescription and calibration of and interferometric method to measure growth of mycobacteria.h[electronic resource]  c2008  aAn interferometer that measures the refractive index changes due to bacterial metabolism is described. The apparatus permits simultaneous and real time measurement of bacterial growth in several samples of slowly growing mycobacteria. The error sources are discussed and the sensitivity of the apparatus is tested. For the species Mycobacterium bovis BCG and M. smegmatis, a relation between refractive index change and bacterial concentration is determined experimentally and the time constant of bacterial growth is measured.  ainterferometry  arefractive index  atuberculosis  aBacterial growth1 aLIMA FILHO, E. S.1 aJARDIM, D. F.1 aFERREIRA, M. A. A.1 aFARIA, C. G. de1 aDUARTE, R. S.1 aLESCHE, B.  tEuropean Biophysics Journalgv. 38, p. 111-119, 2008.