01420nam a2200241 a 450000100080000000500110000800800410001902400360006010000180009624501000011426001880021430000130040252005930041565000110100865000130101965000140103265300310104665300260107765300260110370000180112970000170114770000140116415800262020-01-15       2009    bl uuuu     u00u1 u    #d7 a10.1142/9789814304900_00042DOI1 aCASTRO, A. de  aEvidence of deterministic evolution in the immunological memory process.h[electronic resource]  aIn: INTERNATIONAL SYMPOSIUM ON MATHEMATICAL AND COMPUTATIONAL BIOLOGY, 9., 2009, Brasília, DF. Proceedings... Brasília, DF: BIOMAT Institute for Advanced Studies of Biosystemsc2009  ap. 1-14.  aIn this paper, we study the behavior of immune memory against antigenic mutation. Using a dynamic model proposed by one of the authors in a previous study, we have performed simulations of several inoculations, where in each virtual sample the viral population undergo mutations. Our results suggest that the sustainability of the immunizations is dependent on viral variability and that the memory lifetimes are not random, what condradicts what was suggested by Tarlinton et al.. We show that what may cause an apparent random behavior of the immune memory is the antigenic variability.  aMemory  aMutation  aMutação  aEvolução determinística  aMemória imunológica  aMutação antigênica1 aFRONZA, C. F.1 aHERAI, R. H.1 aALVES, D.