02426nam a2200265 a 450000100080000000500110000800800410001910000180006024501080007826001800018630000190036650000200038552015030040565000190190865000200192765000110194765300200195865300260197865300360200465300230204065300290206370000210209270000230211370000240213615787832020-01-15       2009    bl uuuu     u00u1 u    #d1 aVIEIRA, F. D.  aDatabase modeling and web interface systembon-line genomic association studies.h[electronic resource]  aIn: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 5., 2009, Angra dos Reis. Abstracts book... Angra dos Reis: ABBCBc2009  aNão paginado.  aX-Meeting 2009.  aAnimal selection is an important phase of any animal breeding program. However, if the selection is not based on easily observable (or measurable) traits, then selection is much tricker. One alternative is to use Marker Assisted Selection (MAS), where genetic markers are positively associated with the desired traits (Duran et al., 2009). MAS has been powered by the advent of large scale SNP genotyping technologies which produces thousands (even millions) of markers in a single chip. However, this huge number of genetic markers brings new challenges to the international scientfic community such as database modeling and the development of association analysis tools capable of dealing with greatly increased volume of information (LaFramboise, 2009). Although no format files are widely accepted as standard and the major commercial SNP chip companies (Affymatrix, Illumina) release their results through flat files, some important whole genome association analysis freeware softwares adopt .PED and .MAP format files as input. In this work, we present a database model and a Web parser system that reads flat files (Illumina, Affymetrix) and generates corresponding .PED and .MAP format files. Furthermore, through the Web interface it is possible to run PLINK (Purcell et al., 2007) routines such as some statistical and association analysis. Noteworthy that the database model was designed in order to speed up all the tasks and turn possible to run online any of the implemented routines.  aBioinformatics  aGenetic markers  aModels  aBioinformática  aMarcadores genéticos  aMarker Assisted Selection (MAS)  aModelagem de dados  aSistema de interface web1 aAGOSTINHO, G. C.1 aREGITANO, L. C. A.1 aYAMAGISHI, M. E. B.