01843naa a2200301 a 450000100080000000500110000800800410001902400310006010000150009124501100010626000090021652009670022565000250119265000170121765000260123465000190126065000390127965000140131865000100133265300180134265300230136065300170138365300250140070000180142570000150144370000140145877300690147215242072023-08-17       1994    bl uuuu     u00u1 u    #d7 a10.1002/jlb.56.5.666.2DOI1 aPÉPIN, M.  aCellular composition of Corynebacterium pseudotuberculosis pyogranulomas in sheep.h[electronic resource]  c1994  aAbstract: The cellular composition of 46 pyogranulomas experimentally induced with Corynebacterium pseudotuberculosis in sheep was determined by immunohistochemistry. Lesions localized in inoculation sites or draining lymph nodes consisted of macrophage and lymphocyte layers distributed around a necrotic center and surrounded by a fibrous capsule. In immature lesions, T cells of the CD4+ subset predominated, whereas in mature lesions proportions of CD8+ T lymphocytes and cells expressing the gamma/delta chains for the T cell receptor increased. Numerous pyogranuloma cells expressed the interleukin-2 receptor. In addition to these general characteristics, a large individual variability in the proportions of macrophage and T cell subsets was observed for lesions of the same age, in particular for epithelioid macrophages. This heterogeneity suggests a different cellular pattern in relation to the persistence or the elimination of bacteria by the host.  aBacterial infections  aMicrobiology  aMonoclonal antibodies  aSheep diseases  aCorynebacterium Pseudotuberculosis  aGranuloma  aOvino  aCD4-CD8 Ratio  aComposicao celular  aPiogranuloma  aT-Lymphocyte subsets1 aPITTET, J. C.1 aOLIVER, M.1 aGOHIN, I.  tJournal of Leukocyte Biologygv. 56, n. 5, p.666-670, Nov. 1994.