01710naa a2200265 a 450000100080000000500110000800800410001902400340006010000170009424500700011126000090018152009830019065000210117365000170119465000170121165000110122865000150123965000170125465000190127165000260129065300160131665300150133270000200134777300770136715241882023-08-11       1986    bl uuuu     u00u1 u    #d7 a10.1093/infdis/153.5.9182DOI1 aCRASS, B. A.  aToxin involvement in toxic shock syndrome.h[electronic resource]  c1986  aAbstract: Cultures for Staphylococcus and sera from 434 individuals with confirmed or probable toxic shock syndrome (TSS) were studied. Three hundred forty-eight (91.6%) of the staphylococcal isolates produced TSS toxin-1 (TSST-1) alone or in combination with one or more staphylococcal enterotoxins. Isolates producing both staphylococcal enterotoxin C and TSST-1 had a higher association with non menstrual and fatal cases than did any other toxin combination. The sera of 284 patients with TSS were tested for antibodies to TSST-1, and 234 (82.4%) had no detectable levelof antibody compared with 80 (77.7%) of 103 healthy controls having antibody levels of ?1:800. The sera from patients with TSS also had lower levels of antibody to staphylococcal enterotoxins A, B, and C than did the controls, a result indicating that these subjects may have an immunodeficiency that inhibits the production and/or maintenance of antibodies to the staphylococcal enterotoxins and TSST-1.  aBacterial toxins  aBiosynthesis  aEnterotoxins  aHumans  aImmunology  aSeptic shock  aPatogenicidade  aStaphylococcus Aureus  aMiddle Aged  aVirulencia1 aBERGDOLL, M. S.  tThe Journal of Infectious Diseasesgv. 153, n. 5, p. 918-926, May, 1986.