02383naa a2200301 a 450000100080000000500110000800800410001902400410006010000190010124501160012026000090023652015300024565000090177565000230178465000140180765000230182165000130184465000100185765000100186765000120187765000130188965000150190265300240191765300220194170000160196370000190197977300830199815236572023-06-23       1969    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1139/y69-1562DOI1 aHIDIROGLOU, M.  aSelenium distribution and radiotocopherol metabolism in the pregnant ewe and fetal lamb.h[electronic resource]  c1969  aAbstract: Selenium concentrations were determined at various stages of gestation in the bodies and fetal tissues of 26 ewes fed a nutritional muscular dystrophy (NMD) producing hay for 2 years. Eight of these ewes were injected intramuscularly with 6 mg selenium 10 days before slaughter. Maternal tissues in general contained more selenium than the corresponding fetal tissues. As might be expected, the injection of selenium enhanced tissue concentrations in both ewes and fetuses. The pattern of selenium concentration in the various tissues was similar in dams and fetuses, with kidneys containing highest amounts. Selenium concentrations in the tissues of both ewes and fetuses did not appear to change with the stage of gestation. A single oral dose of radiotocopherol was administered to each of 10 pregnant ewes which had been fed an NMD-inducing hay for 2 years. Animals were slaughtered at 1, 2, 5, and 13 days after the oral dose of vitamin E. It was found that in the ewes, liver and adrenal tissues had a high rate of tocopherol uptake in the first 24 h. Subsequently, the radioactivity fell sharply with time, whereas in heart, muscle, kidney, and lung tissues, in which the initial uptake was lower, the decrease with time was slower. Relative specific activities between maternal and corresponding fetal tissues tended to decrease with time. The ewes excreted more than 70% of the administered radiotocopherol dose within 4 days, primarily via the feces; urinary excretion was comparatively small.  aEwes  aMineral metabolism  aPregnancy  aRuminant nutrition  aSelenium  aSheep  aOvino  aPrenhez  aSelênio  aVitamina E  aLaboratorio clinico  aPatologia clinica1 aHOFFMAN, I.1 aJENKINS, K. I.  tCanadian Journal Physiology Pharmacologygv. 47, n. 11, p. 953-962, Nov. 1969.