01764naa a2200313 a 450000100080000000500110000800800410001902400600006010000200012024501040014026000090024452008460025365000180109965000190111765000200113665000170115665000190117365000100119265000180120265300210122065300170124165300180125865300150127665300320129170000140132370000200133770000170135777300760137415227792023-12-11       1985    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1111/j.1365-2885.1985.tb00956.x2DOI1 aHENNESSY, D. R.  aPotentiation of the anthelmintic activity of oxfenbendazole by parbendazole.h[electronic resource]  c1985  aAbstract: The ability of parbendazole (PBZ) to potentiate co-administered oxfendazole (OFZ) was investigated. Administration of a range (1.35–36.0 mg/kg) of doses of PBZ with 4.53 mg OKZ/kg demonstrated that signilicant potentiation occurred at 4.5 mg PBZ/kg. At 4.5 mg PBZ/kg, the area under the plasma OKZ concentration curve was about twice that obtained from oral administration of OFZ alone. When tested against benzimidazole-resistant Haemonchus contorolus and Trichostrongylus colubriformis, the mixture of 4.5 mg PBZ + 4.53 mg OKZ/kg was significantly more effective than 4.53 mg OFZ/kg alone, and PBZ alone showed no activity against these resistant nematodes. The demonstration of PBZ-OFZ potentiation has indicated a means of obtaining a more effective use of currently available anthelmintics in the treatment of helminthiasis.  aAnthelmintics  aBenzimidazoles  aDrug resistance  aParasitology  aSheep diseases  aOvino  aParasitologia  aAnti-helminticos  aDrug effects  aEndoparasitos  aNematodeos  aResistance to anthelmintics1 aLACEY, E.1 aPRICHARD, R. K.1 aSTEEL, J. W.  tJournal Veterinary Pharmacology Therapicgv. 8, n. 3, p. 270-275, 1985.