02285naa a2200361 a 450000100080000000500110000800800410001902400300006010000170009024501050010726000090021252012930022165000200151465000200153465000130155465000110156765000110157865000240158965000220161365000110163565000090164665000230165565000150167865000260169365000230171965000130174265000190175565000190177465000090179365300210180265300290182377300710185215226162023-06-23       1974    bl uuuu     u00u1 u    #d7 a10.1079/pns19740049.2DOI1 aMILLS, C. F.  aThe detection of trace element deficiency and excess in man and farm animals.h[electronic resource]  c1974  aAbstract: The certainty and speed with which a disorder arising from deficiency or excess of a dietary component can be recognized depends greatly upon the clarity with which the clinical consequences of this disorder have been characterized in experimental studies. Among the many disorders attributable to deficiency or excess of the trace elements only one, ?swayback? in the copper-deficient lamb, can be clearly recognized by its gross signs. With the others the signs are insufficiently specific to achieve a satisfactory diagnosis by consideration of a single gross lesion. In these circumstances, progress towards identification of the disorder must then be achieved by more detailed consideration of the variety of clinical and metabolic lesions, by determination of the trace element content of animal tissues obtained by biopsy or post mortem or, finally, by determination of the trace element content of the diet or other vehicle whereby these elements gain access to the subject. The purpose of this paper is to examine some of these supporting diagnostic procedures and particularly to consider their limitations, where these may originate from inadequacies in experimental studies of the clinical and metabolic consequences of trace element deficiency and excess in animals  aAdverse effects  aCattle diseases  aChromium  aCobalt  aCopper  aDeficiency diseases  aDisease diagnosis  aHumans  aLead  aMetabolic diseases  aMolybdenum  aNutrient requirements  aRuminant nutrition  aSelenium  aSheep diseases  aTrace elements  aZinc  aNutricao mineral  aNutritional Requirements  tProceedings Nutrition Societygv. 33, n. 3, p. 267-279, Dec. 1974.