01856naa a2200313 a 450000100080000000500110000800800410001902400360006010000160009624501180011226000090023052009880023965000130122765000170124065000180125765000100127565000150128565000170130065000220131765000120133965000120135165000120136365300190137570000200139470000220141470000160143670000190145277300710147115217262023-06-30       1980    bl uuuu     u00u1 u    #d7 a10.1099/0022-1317-50-1-69.2DOI1 aNARAYAN, O.  aBiological characterization of the virus causing leukoencephalitis and arthritis in goats.h[electronic resource]  c1980  aAbstract: This study describes the Biological properties of a strain of virus isolated from tissues of a goat with leukoencephalomyelitis-arthritis. The agent is a retrovirus, having a virion-associated reverse transcriptase enzyme and an antigenic determinant(s) which cross-reacts with the p30 of visna-maedi viruses. Morphogenesis of the virus is also similar to visna virus in terms of virus assembly and the multinucleated giant cell formation which accompanies replication of the latter virus. Despite its cytopathogenic property the goat agent was not lytic in goat cell culture, causing instead a productive infection which persisted through multiple subcultures of the cells. The virus replicated incompletely in sheep cell cultures but could be rescued from the latter, weeks after inoculation, by co-cultivation with goat cells. Our data suggest that this strain of goat leukoencephalitis virus is a variant of the ovine retroviruses with a host range limited to the goat.  aAntigens  aEncephalitis  aGoat diseases  aGoats  aImmunology  aRetroviridae  aVisna maedi virus  aArtrite  aCaprino  aDoença  aLeucocephalite1 aCLEMENTS, J. E.1 aSTRANDBERG, J. D.1 aCORK, L. C.1 aGRIFFIN, D. E.  tThe Journal of General Virologygv. 50, n. 1, p. 69-79, Sep. 1980.