02375naa a2200337 a 450000100080000000500110000800800410001902400270006010000180008724501710010526000090027652014030028565000220168865000150171065000160172565000200174165000150176165000170177665000140179365000170180765000100182465000140183465000150184865000100186365000170187365300170189065300100190765300250191770000170194277300780195915213672025-08-14       1976    bl uuuu     u00u1 u    #d7 a10.1071/bi97605652DOI1 aMILLER, B. G.  aEffects of progesterone and oestradiol on RNA and protein metabolism in the genital tract and on survival of embryos in the ovariectomized ewe.h[electronic resource]  c1976  aAbstract: The hormonal regulation of metabolism in the genital tract and the development of embryos during early pregnancy in the ewe have been examined. Ovariectomized ewes received injections of maintenance progesterone, oestrous oestradiol and priming progesterone according to schedules designed to simulate endogenous ovarian secretion during early pregnancy, around the time of oestrus and during the luteal phase of the oestrous cycle immediately preceding oestrus. The survival and development of embryos was dependent upon the dose of maintenaince progesterone and the duration of treatment at the time of transfer, but changes in progesterone dose did not change endometrial protein or RNA metabolism on particular days. Both priming progesterone and oestrous oestradiol were required for normal embryo development. Priming progesterone and oestrous oestradiol each increased endometrial RNA/DNA ratios during early pregnancy. There were no interactions between priming progesterone and oestrous oestradiol, their effects being simply additive. Neither maintenance nor priming progesterone had any effect on protein and RNA metabolism in the oviduct. It is suggested that in the intact ewe oestrogen secreted at oestrus and progesterone secreted prior to oestrus play important roles in the establishment of a uterine environment suitable for the subsequent normal development of embryos.  aAnimal physiology  aCastration  aEndometrium  aFallopian tubes  aMetabolism  aPharmacology  aPregnancy  aProgesterone  aSheep  aEstradiol  aFisiologia  aOvino  aReprodução  aDrug effects  aOvary  aProtein Biosynthesis1 aMOORE, N. W.  tAustralian Journal Biology Sciencegv. 29, n. 5/6, p. 565-573, Dec. 1976.