02560naa a2200361 a 450000100080000000500110000800800410001902400380006010000170009824501400011526000090025552015200026465000230178465000190180765000210182665000210184765000150186865000100188365000150189365000170190865000190192565000210194465000100196565000180197565300180199365300160201165300270202770000160205470000160207070000170208670000210210377300740212415208522023-10-02       1984    bl uuuu     u00u1 u    #d7 a10.1016/0021-9975(84)90063-x2DOI1 aSMITH, W. D.  aManifestations of resistance to ovine ortertagiais associated with immunological responses in the gastric lymph.h[electronic resource]  c1984  aAbstract: Groups of previously infected and worm-free sheep were serially killed up to 10 days after challenge with 50 000 Ostertagia circumcincta larvae. Two similar groups of sheep were killed 10 days after challenge with 1000 larvae. The previously infected sheep were resistant to the smaller challenge dose in that fewer, stunted worms were recovered from them than from controls. However, this resistance was not as marked as that observed in the previously infected sheep which received the large challenge, because proportionally fewer worms were recovered after the 50000 dose and the great majority of these were arrested at the early fourth stage. The gastric lymph ducts of 6 previously infected sheep were cannulated successfully and a marked local immune response was detected in 3 sheep which were challenged with 50 000 larvae. No response was detected in 3 cannulated sheep challenged with 1000 larvae. In the lymph of the 50 000 dose group, a temporary increase in pepsinogen activity suggested that a hypersensitivity reaction related to the presence of large numbers of mucosal mast cells began between 24 and 48 h after challenge. This was followed by marked increases in the cellular and IgA content of lymph, which reached peaks on days 3 and 6, respectively. It is suggested that the response detected in the gastric lymph reflected aspects of a local immune reaction in the abomasal mucosa and that this reaction accounted for the enhanced degree of resistance to the larger challenge dose.  aAntibody formation  aGastric mucosa  aImmunoglobulin A  aImmunoglobulin G  aImmunology  aLymph  aMast cells  aParasitology  aSheep diseases  aAnti-Helmíntico  aOvino  aParasitologia  aOstertagiasis  aPepsinogens  aTrichostrongyloidiasis1 aJACKSON, F.1 aJACKSON, E.1 aWILLIAMS, J.1 aMILLER, H. R. P.  tJournal of Comparative Pathologygv. 94, n. 4, p. 591-601, Oct. 1984.