02350naa a2200325 a 450000100080000000500110000800800410001910000220006024500920008226000090017452014360018365000200161965000200163965000230165965000210168265000200170365000260172365000210174965000190177065000110178965000190180065000100181965000170182965300240184665300110187070000180188170000270189970000180192677300800194415207282023-03-29       1986    bl uuuu     u00u1 u    #d1 aHOHENBOKEN, W. D.  aInheritance of active and passive humoral immunity in ruminants.h[electronic resource]  c1986  aThe active immune system involves phagocytic, cell mediated and humoral processes plus complement proteins, all interacting to protect the individual from pathogenic organisms. Passive immunity is acquired by newborn ungulates by ingestion of immunoglobulins from colostrum. Research in laboratory animals has established that peak antibody synthesis following challenge with a foreign antigen responds readily to directional selection. The increased titre frequently results in enhanced resistance to some diseases but enhanced susceptibility to others. Oregon State University research has produced conflicting results as to the heritability ofthe ability of newborn calves and lambs to acquire and absorb colostral immunoglobulins and as to the heritability of this passive immunity considered asa trait of the dam. Significant differences among breeds, selection lines and strains did exist for level of colostral immunoglobulins, and low levelstand, in oneexperiment, high levelsas well) wereassociated with lowerneonatal survival. In cattle, there was little evidence that either active immune response or level of complement protein C3 was heritable; but in ewes, the antibody titre to a challenge antigen was moderately to highly heritable. The authors speculate that stabilising selection for immune system traits might be most effective to improvegeneralised disease resistanceand overall livestock production efficiency.  aActive immunity  aCattle diseases  aDisease resistance  aHumoral immunity  aImmunoglobulins  aImmunological synapse  aPassive immunity  aSheep diseases  aBovino  aDoença Animal  aOvino  aResistência  aSistema imunologico  aTraits1 aMUGGLI, N. E.1 aBERGGREN-THOMAS, P. L.1 aNORMAN, L. M.  tProceedings New Zealand Society of Animal Productiongv. 46, p. 5-14, 1986.