01996naa a2200301 a 450000100080000000500110000800800410001902400310006010000200009124501390011126000090025052011220025965000240138165000140140565000110141965000280143065000170145865000100147565000190148565000150150465000150151965000140153465000100154865000170155865300240157570000190159977300760161815203942023-11-08       1962    bl uuuu     u00u1 u    #d7 a10.1530/jrf.0.00300742DOI1 aROBINSON, T. J.  aComparative activies of a number of oestrogens when administered intravenously and intramusculary in the sheep.h[electronic resource]  c1962  aAbstract: The activities of six oestrogenic substances were compared when given as a single injection, intravenously (i/v) or intramuscularly (i/m), to spayed progesterone-primed ewes. The following values for the ED50 for oestrous behaviour, with associated 95% fiducial limits, were obtained: Oestradiol-17? (i/v) 16 ?, 25 ? 39; (i/m) 3 ? 7 ? 16; Oestradiol benzoate (i/v) 30 ? 45 ? 69; (i/m) 5 ? 11 ? 23; Oestrone (i/v) 48 ? 96 ? 194; (i/m) No data; Diethylstilboestrol (i/v) 6 ? 10 ? 18; (i/m) 6 ? 10 ? 18; Hexoestrol (i/v) 46 ? 103 ? 234; (i/m) 46 ? 103 ? 234; Methylethylstilboestrol (i/v) ? ? ; (i/m) 130 ? 279 ? 600; They fell into three groups, with the following i/v : i/m ratios: natural oestrogens; oestradiol- 17?, oestradiol benzoate, 4 : 1: synthetic oestrogens; diethylstilboestrol and hexoestrol, 1 : 1 : pro-oestrogen; methylethylstilboestrol, ? : 1. True oestrogens are presumed to accumulate in the reacting tissues with variable efficiencies. Pro-oestrogens, given i/v, are probably ineffective because they are not converted to oestrogens in a manner or at a rate suitable for such accumulation.  aAnimal reproduction  aEstrogens  aEstrus  aIntramuscular injection  aPharmacology  aSheep  aEndocrinologia  aEstrógeno  aFisiologia  aHormônio  aOvino  aReprodução  aEstradiol Congeners1 aBRANDER, W. M.  tJournal of Reproduction and Fertilitygv. 3, n. 1, p. 74-88, Feb. 1962.