02011naa a2200301 a 450000100080000000500110000800800410001910000240006024501330008426000090021752011470022665000140137370000120138770000210139970000220142070000200144270000150146270000210147770000200149870000190151870000170153770000170155470000200157170000180159170000170160970000190162677300640164514907842018-05-25       2007    bl uuuu     u00u1 u    #d1 aMAGALHAES, J. V. de  aA gene in the multidrug and toxic compound extrusion (MATE) family confers aluminum tolerance in sorghum.h[electronic resource]  c2007  aCrop yields are significantly reduced by aluminum toxicity on highly acidic soils, which comprise up to 50% of the world's arable land1-3. Candidate aluminum tolerance proteins include organic acid efflux transporters, with the organic acids forming non-toxic complexes with rhizosphere aluminum1,4. In this study, we used positional cloning to identify the gene encoding a member of the multidrug and toxic compound extrusion (MATE) family, an aluminum-activated citrate transporter, as responsible for the major sorghum (Sorghum bicolor) aluminum tolerance locus, AltsB5 .Polymorphisms in regulatory regions of AltSB are likely to contribute to large allelic effects, acting to increase AltSB expression in the root apex of tolerant genotypes. Furthermore, aluminum-inducible AltSB expression is associated with induction of aluminum tolerance via enhanced root citrate exudation. These findings will allow us to identify superior AltSB haplotypes that can be incorporated via molecular breeding and biotechnology into acid soil breeding programs, thus helping to increase crop yields in developing countries where acidic soils predominate.  aGenética1 aLIU, J.1 aGUIMARAES, C. T.1 aLANA, U. G. de P.1 aALVES, V. M. C.1 aWANG, Y-H.1 aSCHAFFERT, R. E.1 aHOEKENGA, O. A.1 aPINEROS, M. A.1 aSHAFF, J. E.1 aKLEIN, P. E.1 aCARNEIRO, N. P.1 aCOELHO, C. M.1 aTRICK, H. N.1 aKOCHIAN, L. V.  tNature Genetics, New Yorkgv. 39, n. 9, p. 1156-1161, 2007.