01298naa a2200289 a 450000100080000000500110000800800410001902400270006010000140008724500690010126000090017052005290017965000250070865000130073365000220074665000210076865000120078965300160080165300180081765300180083570000220085370000180087570000160089370000150090970000200092477300640094413999632022-12-06       1998    bl uuuu     u00u1 u    #d7 a10.1021/np980023f2DOI1 aOZEKI, A.  aCytotoxic quassinoids from Simaba cedron.h[electronic resource]  c1998  aFour new quassinoids, cedronolactones A?D (1?4), together with nine known compounds, simalikalactone D (5), chaparrinone (6), chaparrin (7), glaucarubolone (8), glaucarubol (9), samaderine Z (10), guanepolide (11), ailanquassin A (12), and polyandrol (13), were isolated from the wood of Simaba cedron. The chemical structures of 1?4 were elucidated on the basis of their chemical and spectral properties. Cedronolactone A (1) was shown to exhibit a significant in vitro cytotoxicity (IC50 0.0074 ?g/mL) against P-388 cells.  achemical composition  atoxicity  aAnálise Química  aPlanta Medicinal  aToxidez  aDrug plants  aPau para tudo  aSimaba cedron1 aHITOTSUYANAGI, Y.1 aHASHIMOTO, E.1 aITOKAWA, H.1 aTAKEYA, K.1 aALVES, S. de M.  tJournal of Natural Productsgv. 61, n. 6, p. 776-780, 1998.