01933naa a2200301 a 450000100080000000500110000800800410001902400550006010000180011524501320013326000090026550000390027452010190031365000180133265000130135065000110136365000170137465000230139165000230141465000170143765000240145465000110147865000140148965000170150365000260152065000200154677300650156613262672023-08-15       2007    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/j.exppara.2006.11.0092DOI1 aANDREOTTI, R.  aA synthetic bmti n-terminal fragment as antigen in bovine immunoprotection against the tick Boophilus microplus in a pen trial.  c2007  aNa publicação: Renato Andreotti.  aCattle tick control remains a serious problem in cattle farms worldwide, due to the limited success achieved with chemicals. Although the use of vaccines for tick control may open possibilities for an integrated approach, the search for other protective antigens is still necessary to improve control. Boophilus microplus is a rich source of BmTIs, serine proteinase inhibitors that are present throughout the tick's lifecycle. The present paper reports a pen trial conducted to evaluate the performance of a synthetic BmTI N-terminal fragment as antigen against the tick in bovines. The trial was conducted with two groups of eight crossbred cattle under controlled infestation: one group was vaccinated with BmTI peptide using saponin as adjuvant and the other was kept as control. Challenge was performed with 15,000 larvae. The specific IgG response was measured by ELISA, with successful outcomes for vaccinated animals. Vaccination resulted in an 18.4% level of efficacy when compared with the control group.  aAnimal health  aAntigens  aCattle  aImmunization  aSerine proteinases  aSynthetic peptides  aTick control  aBoophilus Microplus  aBovino  aCarrapato  aImunização  aInibidor de Proteína  aSanidade Animal  tExperimental Parasitologygv. 116, n. 1, p. 66-70, May 2007.