01855naa a2200289 a 450000100080000000500110000800800410001910000180006024501380007826000090021650000150022552009760024065000230121665000110123965000170125065000160126765300150128365300150129865300260131365300250133965300210136465300260138565300360141170000180144770000140146577300860147912570282020-01-15       2009    bl uuuu     u00u1 u    #d1 aCASTRO, A. de  aA dynamical modeling to study the adaptive immune system and the influence of antibodies in the immune memory.h[electronic resource]  c2009  aCMES 2009.  aImmunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to chall enging problems of modern computing. Simulation systems and mathematical modeling are also beginning use to answer more complex immunological questions as immune memory process and duration of vaccines, where the regulation mechanisms are not still known sufficiently (Lundegaard, Lund, Kesmir, Brunak, Nielsen, 2007). In this article we studied in machina a approach to simulate the process of antigenic mutation and its implications for the process of memory. Our results have suggested that the durability of the immune memory is affected by the process of antigenic mutation.and by populations of soluble antibodies in the blood. The results also strongly suggest that the decrease of the production of antibodies favors the global maintenance of immune memory.  aImmunologic memory  aModels  aImunização  aSimulação  aAnticorpos  aCélulas B  aMemória imunológica  aModelo computacional  aModelo dinâmico  aMutação antigênica  aSistema imunológico adaptativo1 aFRONZA, C. F.1 aALVES, D.  tComputer Modeling in Engineering & Sciences, Duluthgv. 45, n. 1, p. 83-96, 2009.