02519naa a2200397 a 450000100080000000500110000800800410001902200140006002400520007410000160012624501690014226000090031150000180032052013640033865000130170265000180171565000200173365000230175365000130177665000230178965300170181265300160182965300120184565300170185765300180187465300190189265300130191170000200192470000160194470000240196070000240198470000250200870000170203370000290205077300420207921806702025-11-13       2025    bl uuuu     u00u1 u    #d  a1877-26417 ahttps://doi.org/10.1007/s12649-025-03265-52DOI1 aDIAS, I. A.  aExploiting the potential of the aqueous phase of bio-oil in a biorefinery platformbstrategies for the recovery of high-value-added products.h[electronic resource]  c2025  aFirst online.  aThe forestry sector presents significant potential for biomass-based biorefineries. Fast pyrolysis of biomass, followed by fractionation of bio-oil into pyrolytic lignin and an aqueous phase, enables the industrial-scale extraction of valuable compounds. This study identifies the most effective biorefinery route to maximize the aqueous phase’s potential for high-value compound production. The aqueous phase, containing catechol, vanillin, and levoglucosan, was characterized, and ethyl acetate was found to be the most efficient solvent for extracting these compounds due to its efficacy and lower environmental impact. Adsorption studies using sodium bentonite clay, activated carbon, and polydivinylbenzene resin showed that the polymeric resin was the most efficient, and scalable option. The aqueous phase contained catechol (2.04 g/L), vanillin (0.15 g/L), and levoglucosan (15.38 g/L). The optimal biorefinery process involved separating compounds based on polarity, resulting in two liquors: one enriched in phenolic compounds and the other in sugars. The polydivinylbenzene resin successfully removed phenolic compounds, eluting sugars. This approach demonstrated an efficient and scalable method for converting forestry residues into high-value chemicals, thereby contributing to a sustainable economy through an integrated biorefinery strategy.  aCatechol  aEthyl acetate  aGreen chemistry  aPhenolic compounds  aVanillin  aComposto Fenólico  aBiorefinaria  aBiorefinery  aCatecol  aLevoglucosan  aLevoglucosano  aQuímica verde  aVanilina1 aSILVA, D. J. da1 aORSO, G. A.1 aMAGALHAES, W. L. E.1 aMUÑIZ, G. I. B. de1 aMAIA, B. H. L. N. S.1 aMATOS, M. de1 aCADEMARTORI, P. H. G. de  tWaste and Biomass Valorization, 2025.