02583naa a2200349 a 450000100080000000500110000800800410001902400520006010000250011224501680013726000090030552014940031465000170180865000160182565000210184165000290186265300260189165300100191770000250192770000230195270000220197570000190199770000260201670000260204270000360206870000200210470000190212470000230214370000190216670000220218577300260220721765532025-06-11       2025    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1186/s41110-025-00320-y2DOI1 aANDRADE, B. K. DE M.  aEffects of Yacon (Smallanthus sonchifolius) syrup on the glycemic metabolism, and intestinal microbiota of rats on a high‑fat diet.h[electronic resource]  c2025  aHigh-fat diets adversely affect both glycemic control and the composition of the intestinal microbiota. Yacon syrup, which is rich in fructooligosaccharides (FOS) and antioxidants, offers a promising nutritional solution. This study aimed to investigate the impact of Yacon syrup consumption on the intestinal microbiota profile, body weight, food consumption, and glycemic control in rats exposed to a high-fat diet (HFD). Our experimental design involved placing the animals into four distinct groups: (1) rats maintained on a standard diet throughout the experimental protocol, (2) rats consistently fed a high-fat diet, (3) rats exposed to an initial phase of HFD followed by HFD supplemented with 1% FOS in the second phase, and (4) rats following a similar two-phase HFD regimen but with 2% FOS supplementation. We carefully monitored dietary intake and conducted glucose tolerance tests. After the treatment, we performed a 16S rRNA gene analysis of the intestinal microbiota. Our findings revealed a notable increase in the glycemic peak within the first 15 min of high-fat consumption when compared to the supplemented groups. Our findings, observed after 10 weeks of treatment (phase 1, days 1–38; phase 2, days 39–70), revealed a notable increase in the glycemic peak within the first 15 min in the group consistently fed a high-fat diet compared to the supplemented groups. Further, we observed a significant increase in specific pathogenic phyla (notably Proteobacteria  aAntioxidants  aDietary fat  aGlycemic control  aSmallanthus sonchifolius  aIntestinal microbiota  aYacon1 aDANZIATO NETO, M. A.1 aOLIVEIRA, A. C. DE1 aFREITAS, P. A. DE1 aMELO, V. M. M.1 aQUINTELA, B. C. S. F.1 aOLIVEIRA, F. A. DA S.1 aMONTEIRO‑MOREIRA, A. C. DE O.1 aDIONISIO, A. P.1 aADRIANO, L. S.1 aCOSTA, M. A. F. DA1 aALMEIDA, I. F.1 aCARIOCA, A. A. F.  tNutrire, 50:18, 2025.