02542naa a2200229 a 450000100080000000500110000800800410001902200140006002400540007410000230012824501310015126000090028230000100029152018050030165300350210665300370214170000230217870000180220170000190221970000180223877300560225621761112025-05-28       2025    bl uuuu     u00u1 u    #d  a0167-73227 ahttps://doi.org/10.1016/j.molliq.2025.1277032DOI1 aBETRTOLO, M. R. V.  aSustainable extraction of value-added compounds from orange waste using natural deep eutectic solvents.h[electronic resource]  c2025  a12 p.  aOrange peels are considered a major agro-industrial residue from orange fruit processing. Their rich composition can lead to ready-to-use products with antioxidant and antimicrobial properties. However, many conventional methods rely on organic solvents and energy-intensive processes, reducing their environmental friendliness. To address this, sustainable approaches that use greener solvents to extract valuable products from agro-industrial waste are sought after. This study evaluated the use of distinct natural deep eutectic solvents (NADES) for phenolics extraction and hydrodistillation of orange peels, employing an ultrasound-assisted technique. The NADES formulated with betaine and glycerol (BET-GLY) led to the highest total phenolic content (TPC) among the obtained extracts. The extraction was optimized using a Box-Behnken design, leading to a TPC about 31 % higher than under non-optimized conditions. Besides, the optimized extract showed a suitable shelf life, presenting only a 6 % TPC decrease after 6 months of storage. For the hydrodistillation of the peels for essential oil extraction, the NADES based on choline chloride and glycerol (CC-GLY) led to the highest oil yield (24 mg oil g− 1 peel). The essential oil showed growth inhibitions greater than 90 % for both Staphylococcus aureus and Escherichia coli. Finally, both processes were evaluated for their green effectiveness using the Green Certificate method, with scores exceeding 90. The results demonstrate that combining NADES with ultrasound facilitates greener and safer processes by reducing reagents, waste generation, and energy consumption. This approach represents a potential tool for the sustainable production of high-value compounds for the food and pharmaceutical industries using agricultural waste.  aNatural deep eutectic solvents  aUltrasound-assisted extraction G1 aOLIVEIRA, L. F. R.1 aTITATO, G. M.1 aLANÇAS, F. M.1 aCORREA, D. S.  tJournal of Molecular Liquidsgv. 431, 127703, 2025.