02898naa a2200397 a 450000100080000000500110000800800410001902400380006010000230009824501230012126000090024452017490025365000240200265000220202665000180204865000200206665000120208665300240209865300180212265300210214065300160216165300140217770000230219170000260221470000200224070000210226070000240228170000230230570000200232870000200234870000230236870000180239170000200240970000200242977300510244921744662025-04-15       2024    bl uuuu     u00u1 u    #d7 aDOI: 10.1111/1750-3841.173512DOI1 aSILVA, F. T. DE S.  aMicrofiltered red-purple pitaya concentratebA promising multifunctional food-derived colorant.h[electronic resource]  c2024  aRed pitaya fruit has become a source of natural colorant, because it is rich in betalains, a pigment that imparts a red-purple color that inter- ests the food and cosmetics industries. This fruit also possesses high nutritional value, with a range of bioactive compounds known to confer potential health benefits and prevent chronic diseases, such as diabetes, which makes it useful for use as pharmaceutical agents and dietary supplements. In order to improve its technological and biological effects, a concentration will be required. Thus, the microfiltration, followed by vacuum concentration, can be an interesting strat- egy for this purpose. This study aimed to explore tangential microfiltration to produce microfiltered material, which is an important step to obtain the micro- filtered red-purple pitaya concentrate. Therefore, physicochemical and chemical characterization (including 1 H NMR analysis) and biological properties (toxicity and diabetes) of this concentrate were assessed, using adult zebrafish as a model. The results show that microfiltration was carried out efficiently, with an average consumption of 95.75 ± 3.13 and 74.12 ± 3.58 kW h m−3 , varying according to the material used (“unpeeled pitaya pulp” or “pitaya pulp with peel,” respectively). The in vivo tests indicated non-toxicity and hypoglycemic effect of the concen- trate, since the blood glucose levels were significantly lower in the zebrafish groups treated with this concentrate in comparison with that of control group. Thus, this study suggests the potential of microfiltered red-purple pitaya concen- trate as a promising multifunctional food-derived colorant, exhibiting beneficial biological effects far beyond its attractive color.  aBioactive compounds  aDiabetes mellitus  aHyperglycemia  aMicrofiltration  aDiabete  aCompostos bioativos  aHiperglicemia  aMicrofiltração  aPeixe-zebra  aZebrafish1 aVIANA, J. D. DA R.1 aSILVA, M. DE F. G. DA1 aSILVA, G. S. DA1 aGUEDES, M. I. F.1 aREBOUÇAS, E. DE L.1 aSILVA, A. P. A. DA1 aCOUTINHO, M. R.1 aSILVA, A. W. DA1 aSOUZA, A. C. R. de1 aZOCOLO, G. J.1 aMOURA, C. F. H.1 aDIONISIO, A. P.  tJournal of Food Science, 89:6759–6773, 2024.