02649naa a2200373 a 450000100080000000500110000800800410001902400590006010000270011924501390014626000090028552015140029465000180180865000260182665000230185265000480187565000190192365000200194265000190196265000100198165000200199165300170201165300180202865300080204665300280205465300170208270000190209970000200211870000220213870000220216070000200218270000170220277300560221921732212025-02-24       2025    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/j.smallrumres.2025.1074302DOI1 aMAGALHAES, N. M. de A.  aGlobal prevalence of Mycobacterium avium subsp. paratuberculosis in sheepbSystematic review and meta-analysis.h[electronic resource]  c2025  aAbstract: This report presents a systematic review and meta-analysis on the global prevalence of paratuberculosis in sheep, focusing on seropositivity of Mycobacterium avium subspecies paratuberculosis (MAP). This investigation included 1676 records initially, identified from the databases Web of Science, Scopus, Medline and Science Direct. After filtering and reading, twenty-eight articles were selected for the final analysis. The results showed that the pooled prevalence of animals positive for MAP was 8.02 % (95 % CI = 5.04–12.52 %) with significant heterogeneity (I² = 99.3 %), which suggests that there was high variability among results. The prevalence varied according to the continent, such that it was highest in South America (24.45 %) and lowest in Africa (1.34 %). In addition, meta-analysis per herd indicated that the global prevalence was 55.51 % (95 % CI = 44.96–65.58 %), with heterogeneity that was also high (I² = 96.8 %). Analysis of Doi plots demonstrated that there was slight positive asymmetry (LFK index 1.28), which suggests the possibility of publication bias. The meta-analysis demonstrated variation in global prevalence rates of MAP in sheep, with high dissemination among herds, especially in South America and Asia. The heterogeneity of the data indicates methodological differences among studies, thus highlighting the need for standardized investigations to better understand the epidemiology and control of paratuberculosis in sheep globally.  aAnimal health  aDiagnostic techniques  aDisease prevalence  aMycobacterium avium subsp. paratuberculosis  aSheep diseases  aSmall ruminants  aDoença Animal  aOvino  aParatuberculose  aDistribution  aHeterogeneity  aMAP  aOvine Johne’s disease  aPrevalência1 aLIMEIRA, C. H.1 aCOSTA, R. D. L.1 aPORTELA, R. de A.1 aAZEVEDO, S. S. de1 aALVES, F. S. F.1 aALVES, C. J.  tSmall Ruminant Researchgv. 243, 107430, Feb. 2025.