02559naa a2200385 a 450000100080000000500110000800800410001902400520006010000190011224501710013126000090030252013020031165000250161365000200163865000170165865300250167565300190170065300310171965300260175065300230177665300260179965300180182565300280184365300150187170000170188670000220190370000190192570000210194470000190196570000260198470000200201070000170203070000210204777301050206821725332025-02-10       2024    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/j.oooo.2023.11.0072DOI1 aSCHEPANSKI, N.  aEvaluation of photobiomodulation therapy (PBMT) on salivary flow and composition in head and neck cancer patients undergoing radiation therapy.h[electronic resource]  c2024  aObjective Assess the impact of photobiomodulation therapy (PBMT) on xerostomia, salivary flow rate (SFR) and composition in patients undergoing radiotherapy (RT) for head and neck cancer (HNC). Study Design Thirty patients undergoing RT (65 Gy) for HNC were enrolled. Saliva and xerostomia evaluations collected pre- and post-PBMT-RT. PBMT involved irradiation of extra and intraoral points, 15-20 sessions, 2-3 times/week. SFR, trace elements, total protein, alkaline phosphatase, xerostomia, and pH were analyzed. Results The average age was 60.7 years. After treatment, there was not a significant reduction in SFR and there was no difference on xerostomia. Significant reductions in Al, Cd, Fe, Ni, P, and Sb concentrations were observed, along with a significant increase in Mg concentration. Sample data were organized into 3 groups based on a self-organizing map. Low concentrations of Al, As, Co, Cr, Cu, Fe, Mn, Mo, S, Sr, and Zn were the primary discriminatory factors for group A, while group B consisted of post-PBMT-RT samples with high concentrations of Ca, K, Mg, Na, and S. Conclusions PBMT prevented a significant reduction in SFR and xerostomia induced by radiation therapy. These findings suggest that PBMT prevents salivary gland damage minimizing the decline in salivary flow.  aAlkaline phosphatase  aQuality of life  aRadiotherapy  aHead and neck cancer  aHyposalivation  aPhotobiomodulation therapy  aSalivary constituents  aSalivary flow rate  aSalivary gland damage  aTotal protein  aUndergoing radiotherapy  aXerostomia1 aCOSTA, F. S.1 aMACHADO, E. F. M.1 aPACHECO, M. N.1 aAMARAL, C. D. B.1 aMACHADO, R. C.1 aNOGUEIRA, A. R. de A.1 aBRANCHER, J. A.1 aSASSI, L. M.1 aARAUJO, M. R. DE  tOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologygv. 137, n. 3, p. 253-263, mar. 2024.