02471naa a2200349 a 450000100080000000500110000800800410001902400520006010000160011224501730012826000090030152013640031065000240167465000170169865000290171565000120174465000220175665000230177865300190180165300240182065300250184465300210186965300230189070000160191370000250192970000220195470000160197670000240199270000170201670000250203377300630205821647632024-11-08       2024    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1007/s12649-024-02427-12DOI1 aLEAL, F. C.  aPinhão coat (Araucaria angustifolia (Bertol.) Kuntze) nanosuspension as a potential additive in cosmetic formulations with wound healing effect.h[electronic resource]  c2024  aAbstract Purpose Development of a sustainable route to value pinhão (Araucaria angustifolia (Bertol.) Kuntze) coat through mechani- cal defibrillation process and employment as an additive in cosmetic formulations. Methods The pinhão coat nanosuspension (PCN) was added to the Lanette® base at concentrations of 0.5, 1.0, 1.5, and 2.0%. Subsequently, the PCN-based formulations were evaluated concerning their appearance, physiochemical aspects (pH, spreadability, and stability tests), rheological behavior, cytotoxicity, and wound closure capacity. Results The outcomes showed that the PCN addition conferred a light brown milky color to the lotions, besides decreasing the pH values and increasing the spreadability compared to the control formulations. Related to the rheological analysis, the lotions with PCN displayed pseudoplastic behavior, an aspect of strong gel, and were also stable through the thermomechani- cal analysis. The cell viability analysis showed no cytotoxicity of the PCN-based formulations at concentrations inferior to 0.05 mg/mL. Furthermore, the in vitro scratch wound assay revealed that the presence of PCN (1.5 and 2.0%) promoted a complete wound contraction after 72 h of treatment. Conclusion The study demonstrated a sustainable alternative to apply pinhão by-product in cosmetic formulation with wound-healing effects.  aBioactive compounds  aCytotoxicity  aAraucária Angustifólia  aPinhão  aProduto Florestal  aResíduo Orgânico  aCitotoxicidade  aCompostos bioativos  aRheological behavior  aSustentabilidade  aWaste valorization1 aUEDA, K. M.1 aLIMA, T. A. de M. de1 aFREITAS, R. A. de1 aHELM, C. V.1 aMAGALHAES, W. L. E.1 aMAFRA, M. R.1 aIGARASHI‑MAFRA, L.  tWaste and Biomass Valorizationgv. 15, p. 5323-5334, 2024.