02339naa a2200325 a 450000100080000000500110000800800410001902400520006010000160011224501120012826000090024052013670024965000250161665000200164165000140166165000240167565000130169965300320171265300290174465300170177365300160179065300170180665300160182365300270183970000170186670000200188370000160190370000220191977300720194121621542024-02-21       2023    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1007/s00253-023-12656-42DOI1 aTIMM, T. G.  aMushroom β-glucansbapplication and innovation for food industry and immunotherapy.h[electronic resource]  c2023  aAmong the most important sources of β-glucans are edible and medicinal mushrooms. These molecules are components of the cellular wall of basidiomycete fungi (mushrooms) and can be extracted even from the basidiocarp as the mycelium and its cultivation extracts or biomasses. Mushroom β-glucans are recognized by their potential effects as immunostimulants and immunosuppressants. They are highlighted as anticholesterolemic, anti-inflammatory, adjuvant in diabetes mellitus, mycotherapy for cancer treatment, as well as adjuvants for COVID-19 vaccines. Due to their relevance, several techniques of β-glucans extraction, purification, and analysis have already been described. Despite the previous knowledge of β-glucans’ benefits for human nutrition and health, the main information about this topic refers to the molecular identification, proper- ties, and benefits, as well as their synthesis and action on cells. Studies on biotechnology industry applications (product development) and the registered products of β-glucans from mushrooms are still limited and more common for feed and healthcare. In this context, this paper reviews the biotechnological production of food products containing β-glucans from basidiomycete fungi, focusing on food enrichment, and presents a new perspective on fungi β-glucans’ use as potential immunotherapy agents.  aBioactive properties  aFood enrichment  aMushrooms  aProduct development  aCogumelo  aDesenvolvimento de produtos  aEnriquecimento alimentar  aImunoterapia  aMicoterapia  aMmunotherapy  aMycotherapy  aPropriedades bioativas1 aCOSTA, T. M.1 aALBERTON, M. D.1 aHELM, C. V.1 aTAVARES, L. B. B.  tApplied Microbiology and Biotechnologygv. 107, p. 5035-5049, 2023.