03083naa a2200265 a 450000100080000000500110000800800410001902200140006002400510007410000220012524501270014726000090027430000100028352022730029365300300256665300220259665300230261870000220264170000240266370000150268770000220270270000200272470000180274477300550276221607132024-06-11       2024    bl uuuu     u00u1 u    #d  a2666-05397 ahttps://doi.org/10.1016/j.snr.2023.1001842DOI1 aSANTOS, D. M. dos  aLow-cost paper-based sensors modified with curcumin for the detection of ochratoxin a in beverages.h[electronic resource]  c2024  a11 p.  aOchratoxin A (OTA) is a mycotoxin that can contaminate food and is produced by fungal species such as Aspergillus carbonarius, Penicillium verrucosum, Aspergillus ochraceus, and Aspergillus niger [1]. OTA poses significant risks to both humans and animals, as it can cause mutagenic, carcinogenic, teratogenic, hemorrhagic, hepatotoxic, estrogenic, immunotoxic, dermatoxic, nephrotoxic, and neurotoxic effects [2–5]. Contamination with OTA can occur at various stages, including during cultivation, post-harvest, and transportation or storage of food produce. Commonly affected food items include dried fruits, cereals, nuts, corn, oats, coffee, grape juice, wine, wheat, and beer [6–9]. OTA is stable in most food-processing conditions, making it a persistent concern in the realm of food safety [4]. Consumption of OTA-contaminated food has emerged as a substantial public health issue that requires immediate attention. Currently, analytical methods such as enzyme-linked immunosorbent assay (ELISA) [10] and chromatographic assays [11] are employed to detect OTA and monitor food quality. However, these approaches are time-consuming and expensive and require sample preparation and trained personnel to operate the instruments. To address these limitations, alternative systems have been proposed, including electrochemical and optical sensors, which offer simpler procedures for detecting OTA traces [4]. Surface functionalization [5,12,13] can further enhance the performance of these sensors. Notably, paper-based sensors show great promise as they fulfill the requirements for point-of-attention food monitoring, are low-cost, portable, and versatile [14,15]. Additionally, functionalization can be accomplished using a wide range of raw, biodegradable materials [16–18]. In this study, we present an innovative paper-based sensor functionalized with curcumin for the optical and electrochemical detection of ochratoxin A (OTA), as illustrated in Scheme 1. Curcumin is a highly promising sensing element due to its affordability, widespread availability, non-toxicity, and pronounced fluorescence that is quenched in the presence of OTA [19–25]. Notably, curcumin also possesses redox-active properties, with two distinct redox centers: a β-diketone.  aElectrochemical detection  aOptical detection  aPaper-based sensor1 aMIGLIORINI, F. L.1 aCOATRINI-SOARES, A.1 aSOARES, J.1 aMATTOSO, L. H. C.1 aOLIVEIRA, O. N.1 aCORREA, D. S.  tSensors and Actuators Reportsgv. 7, 100184, 2024.